Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Mar 5;93(5):2008-13.
doi: 10.1073/pnas.93.5.2008.

Foldons, protein structural modules, and exons

A R Panchenko  1 , Z Luthey-Schulten, P G Wolynes
Affiliations

Foldons, protein structural modules, and exons

A R Panchenko et al. Proc Natl Acad Sci U S A. .

Abstract

Foldons, which are kinetically competent, quasi-independently folding units of a protein, may be defined using energy landscape analysis. Foldons can be identified by maxima in a scan of the ratio of a contiguous segment's energetic stability gap to the energy variance of that segment's molten globule states, reflecting the requirement of minimal frustration. The predicted foldons are compared with the exons and structural modules for 16 of the 30 proteins studied. Statistical analysis indicates a strong correlation between the energetically determined foldons and Go's geometrically defined structural modules, but there are marked sequence-dependent effects. There is only a weak correlation of foldons to exons. For gammaII-crystallin, myoglobin, barnase, alpha-lactalbumin, and cytochrome c the foldons and some noncontiguous clusters of foldons compare well with intermediates observed in experiment.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. EMBO J. 1994 Mar 15;13(6):1280-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1519-23 - PubMed
    1. Science. 1992 Sep 11;257(5076):1489-90 - PubMed
    1. Biochemistry. 1991 Apr 23;30(16):3816-24 - PubMed
    1. Biochemistry. 1994 Mar 29;33(12):3778-86 - PubMed

Publication types

LinkOut - more resources