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. 1996 Jul;70(7):4761-6.
doi: 10.1128/JVI.70.7.4761-4766.1996.

Phenotypic changes in Langerhans' cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection?

L J Johnston  1 , G M Halliday, N J King
Affiliations

Phenotypic changes in Langerhans' cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection?

L J Johnston et al. J Virol. 1996 Jul.

Abstract

The role of Langerhans cells (LC) in the initiation of an immune response to a viral infection remains unclear. In vivo epidermal infection with the arboviruses West Nile virus and Semliki Forest virus significantly increased the expression of major histocompatibility complex class II antigens, CD54, and CD80 on LC. Thus, during an epidermally acquired viral infection, local LC appear to mature to a phenotype approximating that of lymphoid dendritic cells. This change may be important in the activation of naïve T cells and the subsequent clearance of viral infection.

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References

    1. J Immunol. 1989 Dec 15;143(12):3925-33 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Feb;86(3):911-5 - PubMed
    1. J Invest Dermatol. 1991 Jan;96(1):148-51 - PubMed
    1. Immunology. 1991 Nov;74(3):414-9 - PubMed
    1. J Exp Med. 1992 Oct 1;176(4):1221-6 - PubMed

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