Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing
- PMID: 8626581
- DOI: 10.1074/jbc.271.17.10188
Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing
Abstract
A series of studies has shown that application of transforming growth factor beta (TGF-beta) to a wound has a beneficial effect, especially in animals with wound healing disorders. In this study we have investigated the regulation of TGF-beta1, beta2, and beta3 and their receptors during the repair process. We found a large induction of all three TGF-beta isoforms and also of TGF-beta types I and II receptors, although the time course of induction and the absolute expression levels were different for these genes. Furthermore, each TGF-beta isoform had distinct sites of expression in the wound. Systemic treatment with glucocorticoids significantly altered the expression levels of TGF-betas and TGF-beta receptors. Whereas expression of TGF-beta1, TGF-beta2, and TGF-beta type II receptor was suppressed by glucocorticoids in normal and wounded skin, expression of TGF-beta3 and TGF-beta receptor type I mRNA was stimulated. These findings provide an explanation for the beneficial effect of exogenous TGF-beta in the treatment of impaired wound healing in glucocorticoid-treated animals. Furthermore, they suggest that a disturbed balance between the levels of the three TGF- beta isoforms and their receptors might underlie the wound healing defect seen in glucocorticoid-treated animals.
Similar articles
-
Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing.Biofactors. 2002;16(1-2):29-43. doi: 10.1002/biof.5520160104. Biofactors. 2002. PMID: 12515914
-
Transforming growth factors beta1, beta2 and beta3 and their receptors are differentially expressed in human peritoneal fibroblasts in response to hypoxia.Am J Reprod Immunol. 2002 Dec;48(6):387-93. doi: 10.1034/j.1600-0897.2002.01090.x. Am J Reprod Immunol. 2002. PMID: 12607775
-
Rapid closure of midgestational excisional wounds in a fetal mouse model is associated with altered transforming growth factor-beta isoform and receptor expression.J Pediatr Surg. 2007 Jun;42(6):966-71; discussion 971-3. doi: 10.1016/j.jpedsurg.2007.01.055. J Pediatr Surg. 2007. PMID: 17560204
-
Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis.Wound Repair Regen. 2016 Mar;24(2):215-22. doi: 10.1111/wrr.12398. Epub 2016 Mar 2. Wound Repair Regen. 2016. PMID: 26704519 Review.
-
The role of growth factors in peritoneal healing: transforming growth factor beta (TGF-beta).Eur J Surg Suppl. 1997;(577):17-23. Eur J Surg Suppl. 1997. PMID: 9076448 Review.
Cited by
-
Transforming growth factor-beta expression in human placenta and placental bed in third trimester normal pregnancy, preeclampsia, and fetal growth restriction.Am J Pathol. 2001 Nov;159(5):1827-38. doi: 10.1016/s0002-9440(10)63029-5. Am J Pathol. 2001. PMID: 11696443 Free PMC article.
-
Fibromodulin-deficiency alters temporospatial expression patterns of transforming growth factor-β ligands and receptors during adult mouse skin wound healing.PLoS One. 2014 Mar 6;9(6):e90817. doi: 10.1371/journal.pone.0090817. eCollection 2014. PLoS One. 2014. PMID: 24603701 Free PMC article.
-
Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases.Environ Health Perspect. 1997 Sep;105 Suppl 5(Suppl 5):1197-203. doi: 10.1289/ehp.97105s51197. Environ Health Perspect. 1997. PMID: 9400723 Free PMC article.
-
Abnormal cell responses and role of TNF-α in impaired diabetic wound healing.Biomed Res Int. 2013;2013:754802. doi: 10.1155/2013/754802. Epub 2013 Jan 20. Biomed Res Int. 2013. PMID: 23484152 Free PMC article. Review.
-
TGF-beta receptor expression in human odontoblasts and pulpal cells.Histochem J. 1999 Aug;31(8):565-9. doi: 10.1023/a:1003852409574. Histochem J. 1999. PMID: 10507464
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
