doi: 10.1006/dbio.1996.0047.
The role of interleukin-4 in the regulation of mouse primordial germ cell numbers
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- PMID: 8626013
- DOI: 10.1006/dbio.1996.0047
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The role of interleukin-4 in the regulation of mouse primordial germ cell numbers
Dev Biol.
.
Free article
Abstract
Interleukin-4 (IL-4), a pleiotropic cytokine, stimulates a dose-dependent increase in the number of mouse primordial germ cells in culture. Results from bromodeoxyuridine incorporation assays suggest that IL-4 acts as a survival factor rather than as a mitogen for primordial germ cells in this system. Studies on the embryonic expression patterns of IL-4 and its receptors, using RT-PCR and ELISA, show that IL-4 and its receptors are present at the correct time and place to influence PGC numbers in vivo.
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