Porphyromonas gingivalis: a proteinase/gene accounting audit
- PMID: 8574516
- DOI: 10.1016/s0966-842x(00)88996-9
Porphyromonas gingivalis: a proteinase/gene accounting audit
Abstract
Analysis of the available data on the Porphyromonas gingivalis proteinase system suggests that at most three different genes encode arginine-X- and lysine-X-specific cysteine proteinases. These are synthesized as polyproteins containing a prepropeptide, a catalytic domain and a hemagglutinin domain. Post-translational processing of each precursor is responsible for the variety of proteinase forms that are seen.
Similar articles
-
Characterization of a Porphyromonas gingivalis gene prtK that encodes a lysine-specific cysteine proteinase and three sequence-related adhesins.Oral Microbiol Immunol. 1999 Apr;14(2):92-7. doi: 10.1034/j.1399-302x.1999.140203.x. Oral Microbiol Immunol. 1999. PMID: 10219167
-
Cloning and sequencing of the gene encoding a novel lysine-specific cysteine proteinase (Lys-gingipain) in Porphyromonas gingivalis: structural relationship with the arginine-specific cysteine proteinase (Arg-gingipain).J Biochem. 1996 Aug;120(2):398-406. doi: 10.1093/oxfordjournals.jbchem.a021426. J Biochem. 1996. PMID: 8889827
-
Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity.Biol Chem. 1998 Feb;379(2):205-11. doi: 10.1515/bchm.1998.379.2.205. Biol Chem. 1998. PMID: 9524073
-
Proteases and collagenases of Porphyromonas gingivalis.Adv Dent Res. 1995 Feb;9(1):37-40. doi: 10.1177/08959374950090010701. Adv Dent Res. 1995. PMID: 7669212 Review.
-
Role of gingipains R in the pathogenesis of Porphyromonas gingivalis-mediated periodontal disease.Clin Infect Dis. 1999 Mar;28(3):456-65. doi: 10.1086/515156. Clin Infect Dis. 1999. PMID: 10194062 Review.
Cited by
-
[Pathogenesis of parodontitis in rheumatic diseases].Z Rheumatol. 2010 Mar;69(2):109-12, 114-6. doi: 10.1007/s00393-009-0560-1. Z Rheumatol. 2010. PMID: 20107818 Review. German.
-
Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase.J Biol Chem. 2015 Nov 6;290(45):27248-27260. doi: 10.1074/jbc.M115.648782. Epub 2015 Sep 18. J Biol Chem. 2015. PMID: 26385924 Free PMC article.
-
Molecular mechanism for connective tissue destruction by dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis.Infect Immun. 2005 May;73(5):2655-64. doi: 10.1128/IAI.73.5.2655-2664.2005. Infect Immun. 2005. PMID: 15845467 Free PMC article.
-
Enzymatic properties of dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis and its participation in virulence.Infect Immun. 2000 Feb;68(2):716-24. doi: 10.1128/IAI.68.2.716-724.2000. Infect Immun. 2000. PMID: 10639438 Free PMC article.
-
Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains.J Clin Invest. 1997 Jun 1;99(11):2574-80. doi: 10.1172/JCI119445. J Clin Invest. 1997. PMID: 9169486 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources