doi: 10.1016/0014-2999(95)00554-x.
Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi]
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- PMID: 8566146
- DOI: 10.1016/0014-2999(95)00554-x
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Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi]
Eur J Pharmacol.
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Abstract
We examined the effects of i.c.v. treatment with naltrindole, and the two highly selective peptide delta-opioid receptor antagonists H-Tyr-Tic-Phe-Phe-OH (TIPP) and H-Tyr-Tic psi [CH2-NH]-Phe-Phe- OH (TIPP[psi]), on the development of morphine tolerance and dependence. Each treatment significantly decreased naloxone-precipitated withdrawal, with TIPP[psi] reducing the most symptoms. TIPP[psi], but neither naltrindole nor TIPP, attenuated the development of analgesic tolerance in the tail-flick test. These results suggest that delta-opioid receptors are critically involved in the development of morphine tolerance and dependence.
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