New synthetic amphiphilic polymers for steric protection of liposomes in vivo
- PMID: 8537880
- DOI: 10.1002/jps.2600840904
New synthetic amphiphilic polymers for steric protection of liposomes in vivo
Abstract
Carboxy group-terminated synthetic polymers--branched poly(ethylene glycol), poly(acryloylmorpholine), and poly(vinylpyrrolidone)--were made amphiphilic by derivatization with phosphatidyl ethanolamine via the terminal carboxy group and then incorporated into lecithin-cholesterol liposomes prepared by the detergent dialysis method. Following the biodistribution of liposomes in mice, all three polymers were shown to be effective steric protectors for liposomes and were able to sharply increase liposome circulation times in a concentration-dependent manner. The accumulation of liposomes in the liver decreases. The effects observed are similar to those found for liposomes modified with linear poly(ethylene glycol). At low polymer concentration, amphiphilic branched poly(ethylene glycol) seems to be the most effective liposome protector, most probably, because at the same molar content of anchoring groups, each attachment point carries two polymeric chains and doubles the quantity of liposome-grafted polymer comparing to linear poly(ethylene glycol).
Similar articles
-
Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo.Biochim Biophys Acta. 1994 Oct 12;1195(1):181-4. doi: 10.1016/0005-2736(94)90025-6. Biochim Biophys Acta. 1994. PMID: 7918561
-
Amphiphilic poly-N-vinylpyrrolidones: synthesis, properties and liposome surface modification.Biomaterials. 2001 Nov;22(22):3035-44. doi: 10.1016/s0142-9612(01)00050-3. Biomaterials. 2001. PMID: 11575478
-
The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes.J Control Release. 2015 Sep 10;213:1-9. doi: 10.1016/j.jconrel.2015.06.023. Epub 2015 Jun 18. J Control Release. 2015. PMID: 26093095 Free PMC article.
-
Polymer-coated long-circulating microparticulate pharmaceuticals.J Microencapsul. 1998 Jan-Feb;15(1):1-19. doi: 10.3109/02652049809006831. J Microencapsul. 1998. PMID: 9463803 Review.
-
Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review.Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):427-43. doi: 10.1016/j.ejpb.2013.07.002. Epub 2013 Jul 17. Eur J Pharm Biopharm. 2013. PMID: 23872180 Review.
Cited by
-
Stealth properties to improve therapeutic efficacy of drug nanocarriers.J Drug Deliv. 2013;2013:374252. doi: 10.1155/2013/374252. Epub 2013 Mar 7. J Drug Deliv. 2013. PMID: 23533769 Free PMC article.
-
Micellar nanocarriers: pharmaceutical perspectives.Pharm Res. 2007 Jan;24(1):1-16. doi: 10.1007/s11095-006-9132-0. Epub 2006 Nov 16. Pharm Res. 2007. PMID: 17109211 Review.
-
Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential.Int J Nanomedicine. 2006;1(3):297-315. Int J Nanomedicine. 2006. PMID: 17717971 Free PMC article. Review.
-
Main Chain Polysulfoxides as Active 'Stealth' Polymers with Additional Antioxidant and Anti-Inflammatory Behaviour.Int J Mol Sci. 2019 Sep 17;20(18):4583. doi: 10.3390/ijms20184583. Int J Mol Sci. 2019. PMID: 31533205 Free PMC article.
-
Liposomal nanoparticles encapsulating iloprost exhibit enhanced vasodilation in pulmonary arteries.Int J Nanomedicine. 2014 Jul 7;9:3249-61. doi: 10.2147/IJN.S63190. eCollection 2014. Int J Nanomedicine. 2014. PMID: 25045260 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
