Molecular biology of the opioid receptors: structures, functions and distributions
- PMID: 8532211
- DOI: 10.1016/0168-0102(95)00933-k
Molecular biology of the opioid receptors: structures, functions and distributions
Abstract
Opiates like morphine and endogenous opioid peptides exert their pharmacological and physiological effects through binding to their endogenous receptors, opioid receptors. The opioid receptors are classified into at least three types, mu-, delta- and kappa-types. Recently, cDNAs of the opioid receptors have been cloned and have greatly advanced our understanding of their structure, function and expression. This review focuses on the recent advances in the studies on opioid receptors using the cloned cDNAs. We describe the molecular cloning of the opioid receptor gene family and studies of the structure-function relationships, modes of coupling to second messenger systems, pharmacological effects of antisense oligonucleotide and anatomical distributions of opioid receptors.
Similar articles
-
Molecular pharmacology of the opioid receptors.Pharmacol Ther. 1995;68(3):343-64. doi: 10.1016/0163-7258(95)02011-x. Pharmacol Ther. 1995. PMID: 8788562 Review.
-
Molecular biology of opioid receptors: recent advances.Neuroimmunomodulation. 1997 Sep-Dec;4(5-6):285-97. doi: 10.1159/000097349. Neuroimmunomodulation. 1997. PMID: 9650823 Review.
-
Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides.Cell Mol Neurobiol. 1995 Dec;15(6):615-35. doi: 10.1007/BF02071128. Cell Mol Neurobiol. 1995. PMID: 8719033 Review.
-
Opioids in chronic pain.Eur J Pharmacol. 2001 Oct 19;429(1-3):79-91. doi: 10.1016/s0014-2999(01)01308-5. Eur J Pharmacol. 2001. PMID: 11698029 Review.
-
[Molecular pharmacology of opioid receptors].Nihon Yakurigaku Zasshi. 2004 Feb;123(2):95-104. doi: 10.1254/fpj.123.95. Nihon Yakurigaku Zasshi. 2004. PMID: 14745129 Japanese.
Cited by
-
Use of opioids to treat chronic, noncancer pain.West J Med. 2000 Feb;172(2):107-15. doi: 10.1136/ewjm.172.2.107. West J Med. 2000. PMID: 10693373 Free PMC article. No abstract available.
-
An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989.J Nucl Med. 2014 Jul;55(7):1185-91. doi: 10.2967/jnumed.114.138701. Epub 2014 May 22. J Nucl Med. 2014. PMID: 24854795 Free PMC article.
-
Inactivation of the purified bovine mu opioid receptor by sulfhydryl reagents.Neurochem Res. 1999 Jan;24(1):37-42. doi: 10.1023/a:1020923928936. Neurochem Res. 1999. PMID: 9973235
-
Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord.Br J Pharmacol. 2015 Jan;172(2):630-41. doi: 10.1111/bph.12790. Br J Pharmacol. 2015. PMID: 24866991 Free PMC article.
-
Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2.Neuroscience. 1999 Mar;90(3):1051-9. doi: 10.1016/s0306-4522(98)00514-4. Neuroscience. 1999. PMID: 10218804 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
