doi: 10.1073/pnas.92.25.11598.
Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor
Affiliations
- PMID: 8524811
- PMCID: PMC40449
- DOI: 10.1073/pnas.92.25.11598
Item in Clipboard
Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor
Proc Natl Acad Sci U S A.
.
Abstract
GATA-1 is a zinc-finger transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. In human and murine erythroid cells a previously undescribed 40-kDa protein is detected with GATA-1-specific antibodies. We show that the 40-kDa GATA-1 (GATA-1s) is produced by the use of an internal AUG initiation codon in the GATA-1 transcript. The GATA-1 proteins share identical binding activity and form heterodimers in erythroleukemic cells but differ in their transactivation potential and in their expression in developing mouse embryos.
Similar articles
-
GATA-and SP1-binding sites are required for the full activity of the tissue-specific promoter of the tal-1 gene.Oncogene. 1994 Sep;9(9):2623-32. Oncogene. 1994. PMID: 8058326
-
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8705-10. doi: 10.1073/pnas.96.15.8705. Proc Natl Acad Sci U S A. 1999. PMID: 10411939 Free PMC article.
-
Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.Mol Cell Biol. 2005 Sep;25(17):7412-22. doi: 10.1128/MCB.25.17.7412-7422.2005. Mol Cell Biol. 2005. PMID: 16107690 Free PMC article.
-
Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis.Nature. 1993 Apr 1;362(6419):466-8. doi: 10.1038/362466a0. Nature. 1993. PMID: 8464479
-
GATA-1: friends, brothers, and coworkers.Ann N Y Acad Sci. 2004 Dec;1030:537-54. doi: 10.1196/annals.1329.064. Ann N Y Acad Sci. 2004. PMID: 15659837 Review.
Cited by
-
Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo.Nucleic Acids Res. 2005 Mar 1;33(4):1298-308. doi: 10.1093/nar/gki248. Print 2005. Nucleic Acids Res. 2005. PMID: 15741183 Free PMC article.
-
Distinct clones are associated with the development of transient myeloproliferative disorder and acute megakaryocytic leukemia in a patient with Down syndrome.Int J Hematol. 2007 Oct;86(3):250-2. doi: 10.1532/IJH97.07058. Int J Hematol. 2007. PMID: 17988992
-
A novel form of pRb expressed during normal myelopoiesis and in tumour-associated macrophages.Cell Prolif. 2005 Feb;38(1):13-24. doi: 10.1111/j.1365-2184.2005.00326.x. Cell Prolif. 2005. PMID: 15679863 Free PMC article.
-
The Genome-Wide Characterization of Alternative Splicing and RNA Editing in the Development of Coprinopsis cinerea.J Fungi (Basel). 2023 Sep 9;9(9):915. doi: 10.3390/jof9090915. J Fungi (Basel). 2023. PMID: 37755023 Free PMC article.
-
Chromosomal mapping and developmental study of Tattered-Hokkaido (Tdho).Mamm Genome. 1997 Aug;8(8):578-80. doi: 10.1007/s003359900507. Mamm Genome. 1997. PMID: 9250864
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
