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. 1996 Jan;70(1):663-6.
doi: 10.1128/JVI.70.1.663-666.1996.

bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation

C W Olsen  1 , J C Kehren, N R Dybdahl-Sissoko, V S Hinshaw
Affiliations

bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation

C W Olsen et al. J Virol. 1996 Jan.

Abstract

We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein.

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