Rat cortical and trabecular bone collagen glycosylation are differently influenced by ovariectomy
- PMID: 8507198
- DOI: 10.1006/bbrc.1993.1555
Rat cortical and trabecular bone collagen glycosylation are differently influenced by ovariectomy
Abstract
This study sought to evaluate whether estrogen depletion influences the hydroxylysine glycosydes content of rat bone collagen. For this reason thirty 100 day old female rats were divided in 6 groups of 5 rats each. Three groups were ovariectomized and 3 groups were sham-operated. The animals were sacrificed at 115, 130 and 145 days of age (i.e., 15, 30 and 45 days after surgery). Cortical and trabecular bone was prepared from tibiae and femurs. Hydroxylysine glycosydes content was measured by HPLC. Ovariectomy is followed, in the rat, by an increased hydroxylysine glycosylation in trabecular bone but by a constant or slightly decreased hydroxylysine glycosylation in the cortical bone. In view of the different effects of estrogens on the two bone compartments previously reported, a possible functional explanation of these findings is proposed.
Similar articles
-
Collagen type I of rat cortical and trabecular bone differs in the extent of posttranslational modifications.Calcif Tissue Int. 1996 Jan;58(1):65-9. doi: 10.1007/BF02509548. Calcif Tissue Int. 1996. PMID: 8825241
-
17 beta-Estradiol and tamoxifen prevent the over-glycosylation of rat trabecular bone collagen induced by ovariectomy.Eur J Clin Chem Clin Biochem. 1997 Jan;35(1):29-33. doi: 10.1515/cclm.1997.35.1.29. Eur J Clin Chem Clin Biochem. 1997. PMID: 9156563
-
The influence of orchidectomy on collagen glycosylation of trabecular bone in rat.Eur J Clin Chem Clin Biochem. 1997 Apr;35(4):269-73. doi: 10.1515/cclm.1997.35.4.269. Eur J Clin Chem Clin Biochem. 1997. PMID: 9166968
-
Ovariectomy in the rat induces a rapid increase in the urinary excretion of hydroxylysine glycosides and non-reducible crosslink residues.Osteoporos Int. 1997;7(6):539-43. doi: 10.1007/BF02652559. Osteoporos Int. 1997. PMID: 9604049
-
Collagen glycosylation.Curr Opin Struct Biol. 2019 Jun;56:131-138. doi: 10.1016/j.sbi.2019.01.015. Epub 2019 Feb 26. Curr Opin Struct Biol. 2019. PMID: 30822656 Review.
Cited by
-
Mechano-regulation of collagen biosynthesis in periodontal ligament.J Prosthodont Res. 2014 Oct;58(4):193-207. doi: 10.1016/j.jpor.2014.08.003. Epub 2014 Oct 11. J Prosthodont Res. 2014. PMID: 25311991 Free PMC article. Review.
-
Soy protein improves tibial whole-bone and tissue-level biomechanical properties in ovariectomized and ovary-intact, low-fit female rats.Bone Rep. 2018 May 18;8:244-254. doi: 10.1016/j.bonr.2018.05.002. eCollection 2018 Jun. Bone Rep. 2018. PMID: 29922706 Free PMC article.
-
Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture.J Biol Chem. 2011 Mar 18;286(11):8846-56. doi: 10.1074/jbc.M110.178509. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220425 Free PMC article.
-
Collagen type I of rat cortical and trabecular bone differs in the extent of posttranslational modifications.Calcif Tissue Int. 1996 Jan;58(1):65-9. doi: 10.1007/BF02509548. Calcif Tissue Int. 1996. PMID: 8825241
-
Comprehensive Characterization of Glycosylation and Hydroxylation of Basement Membrane Collagen IV by High-Resolution Mass Spectrometry.J Proteome Res. 2016 Jan 4;15(1):245-58. doi: 10.1021/acs.jproteome.5b00767. Epub 2015 Dec 9. J Proteome Res. 2016. PMID: 26593852 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
