doi: 10.1016/0014-5793(93)81108-c.
Monoclonal anti-biotin antibodies simulate avidin in the recognition of biotin
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- PMID: 8482366
- DOI: 10.1016/0014-5793(93)81108-c
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Monoclonal anti-biotin antibodies simulate avidin in the recognition of biotin
FEBS Lett.
.
Free article
Abstract
The sequence of the VH gene of a monoclonal anti-biotin antibody was determined. Biotin-binding motifs, similar to those in avidin and streptavidin, were identified in complementary determining regions 2 and 3, suggesting that natural selection of functional motifs may occur in unrelated protein types.
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