Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
- PMID: 8456300
- DOI: 10.1126/science.8456300
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
Abstract
Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma had impaired production of macrophage antimicrobial products and reduced expression of macrophage major histocompatibility complex class II antigens. IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen. After a mixed lymphocyte reaction, T cell cytolytic activity was enhanced against allogeneic target cells. Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system.
Comment in
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Immunology. Interfering with interferon.Science. 1993 Mar 19;259(5102):1693-4. doi: 10.1126/science.8456294. Science. 1993. PMID: 8456294 No abstract available.
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