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. 1993 Jan;61(1):142-5.
doi: 10.1128/iai.61.1.142-145.1993.

T-lymphocyte response in a guinea pig model of tuberculous pleuritis

S W Phalen  1 , D N McMurray
Affiliations

T-lymphocyte response in a guinea pig model of tuberculous pleuritis

S W Phalen et al. Infect Immun. 1993 Jan.

Abstract

The ability to induce tuberculous pleuritis in Mycobacterium bovis BCG-vaccinated guinea pigs was investigated as a model of human disease. A pleural effusion of 5 to 10 ml was obtained 6 to 7 days after the bilateral pleural injection of a suspension of heat-killed M. tuberculosis cells. Histological lesions were indicative of granulomatous pleuritis. Comparative studies of T lymphocytes obtained from pleural fluid and peripheral blood revealed increased antigen-driven lymphoproliferation and E rosette formation in pleural effusion lymphocytes. The CD2+ T-lymphocyte population appeared to be expanded or concentrated in pleural fluid, suggesting a compartmentalization of antigen-reactive T lymphocytes. These data demonstrate that experimental tuberculous pleuritis with effusion, closely resembling the human disease, can be produced in BCG-vaccinated guinea pigs.

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