Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Oct 15;90(20):9717-20.
doi: 10.1073/pnas.90.20.9717.

A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4

M F Lyon  1 , B W Ogunkolade, M C Brown, D J Atherton, V H Perry
Affiliations

A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4

M F Lyon et al. Proc Natl Acad Sci U S A. .

Abstract

When a nerve axon is cut or crushed, the nerve fibers in the distal part of the axon, separated from the cell body, undergo a form of spontaneous degeneration, known as Wallerian degeneration. A substrain of the mouse inbred strain C57BL, known as C57BL/Ola, carries a mutant form of a gene involved in Wallerian degeneration in the peripheral and central nervous systems, and in retrograde degeneration of retinal ganglion cells. Wallerian degeneration in this substrain is abnormally slow. Previously the defect had been shown to be due to an autosomal dominant gene. The locus has been given the name and symbol Wallerian degeneration Wld, with the mutant allele Wlds (Wallerian degeneration-slow). The Wld locus has now been mapped, by using conventional and molecular markers, to the distal end of chromosome 4, near the locus of pronatriodilatin (Pnd). The order of loci (with recombination distances in centimorgans, cM) is cen-D4Mit11-8.9 +/- 1.7 cM-Fuca-2.5 +/- 0.93 cM-Akp-2-3.2 +/- 1.1 cM-D4Mit48-3.5 +/- 1.1 cM-(Wld, Pnd, D4Mit49)-0.71 +/- 0.50 cM-(Eno-1, D4Mit33)-1.4 +/- 0.70 cM-D4Mit42-2.5 +/- 0.93 cM-D4Smh6b. The information on the position of the Wld locus should be valuable in further characterization of this gene involved in nerve degeneration and regeneration.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Eur J Neurosci. 1989;1(1):27-33 - PubMed
    1. Mamm Genome. 1991;1(4):273-82 - PubMed
    1. Mamm Genome. 1992;3 Spec No:S55-64 - PubMed
    1. Genetics. 1992 Jun;131(2):423-47 - PubMed
    1. Eur J Neurosci. 1990;2(5):408-13 - PubMed

Publication types

LinkOut - more resources