doi: 10.1016/0092-8674(93)90722-3.
Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins
Affiliations
- PMID: 8402888
- DOI: 10.1016/0092-8674(93)90722-3
Item in Clipboard
Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins
Cell.
.
Abstract
In budding yeast, G1 cyclins such as CLN1 and CLN2 are expressed in G1 and S phases, while mitotic cyclins such as CLB1 and CLB2 are expressed in G2 and M phases. We find that the CLBs play a central role in the transition from CLNs to CLBs: the CLBs stimulate their own expression while repressing that of CLNs. This negative regulation of CLNs may occur via the transcription factor SWI4, because CLBs are necessary for G2 repression of SCB-regulated genes like CLN1 and CLN2 but not for repression of MCB-regulated genes like DNA polymerase and CLB5. Furthermore, SW14 associates with CLB2 protein and is a substrate for the CLB2-associated CDC28 kinase in vitro.
Similar articles
-
Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2.Genes Dev. 1996 Jan 15;10(2):129-41. doi: 10.1101/gad.10.2.129. Genes Dev. 1996. PMID: 8566747
-
The Saccharomyces cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6.Mol Cell Biol. 1996 Jun;16(6):2647-55. doi: 10.1128/MCB.16.6.2647. Mol Cell Biol. 1996. PMID: 8649372 Free PMC article.
-
Three independent forms of regulation affect expression of HO, CLN1 and CLN2 during the cell cycle of Saccharomyces cerevisiae.Genetics. 1994 Dec;138(4):1015-24. doi: 10.1093/genetics/138.4.1015. Genetics. 1994. PMID: 7896087 Free PMC article.
-
G1 control in yeast and animal cells.Ciba Found Symp. 1992;170:7-15; discussion 15-9. doi: 10.1002/9780470514320.ch2. Ciba Found Symp. 1992. PMID: 1483351 Review.
-
Saccharomyces cerevisiae cell cycle: cdc28 and the G1 cyclins.Semin Cell Biol. 1991 Aug;2(4):205-12. Semin Cell Biol. 1991. PMID: 1842339 Review.
Cited by
-
IRIS: a method for reverse engineering of regulatory relations in gene networks.BMC Bioinformatics. 2009 Dec 23;10:444. doi: 10.1186/1471-2105-10-444. BMC Bioinformatics. 2009. PMID: 20030818 Free PMC article.
-
A novel genetic screen implicates Elm1 in the inactivation of the yeast transcription factor SBF.PLoS One. 2008 Jan 30;3(1):e1500. doi: 10.1371/journal.pone.0001500. PLoS One. 2008. PMID: 18231587 Free PMC article.
-
Members of the NAP/SET family of proteins interact specifically with B-type cyclins.J Cell Biol. 1995 Aug;130(3):661-73. doi: 10.1083/jcb.130.3.661. J Cell Biol. 1995. PMID: 7622566 Free PMC article.
-
A continuous-time stochastic Boolean model provides a quantitative description of the budding yeast cell cycle.Sci Rep. 2022 Nov 24;12(1):20302. doi: 10.1038/s41598-022-24302-6. Sci Rep. 2022. PMID: 36434030 Free PMC article.
-
Control of cell cycle transcription during G1 and S phases.Nat Rev Mol Cell Biol. 2013 Aug;14(8):518-28. doi: 10.1038/nrm3629. Nat Rev Mol Cell Biol. 2013. PMID: 23877564 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
