doi: 10.1126/science.8385799.
Distinct functions of SR proteins in alternative pre-mRNA splicing
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- PMID: 8385799
- DOI: 10.1126/science.8385799
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Distinct functions of SR proteins in alternative pre-mRNA splicing
Science.
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Abstract
Alternative splicing of precursor messenger RNAs (pre-mRNAs) is a common mechanism of regulating gene expression. SR proteins are a family of pre-mRNA splicing factors that are structurally related and evolutionarily conserved. Any member of the SR family can complement a splicing-deficient extract that lacks the entire family of SR proteins. Here it is demonstrated that particular SR proteins have distinct functions in alternative pre-mRNA splicing in vitro. In addition, SR proteins are differentially expressed in a variety of tissues. These results suggest a fundamental role for SR proteins in the regulation of alternative splicing.
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