Role of infection due to Campylobacter jejuni in the initiation of Guillain-Barré syndrome
- PMID: 8353228
- DOI: 10.1093/clinids/17.1.104
Role of infection due to Campylobacter jejuni in the initiation of Guillain-Barré syndrome
Abstract
Recent reports suggest that infection with Campylobacter jejuni, a common enteric pathogen, may cause Guillain-Barré syndrome (GBS) by triggering demyelination of peripheral nerves. GBS is preceded by an acute infectious illness (due to a variety of agents) in 50%-75% of cases; the onset of neurological symptoms is preceded by diarrhea in 10%-30% of cases. In the last decade, more than 20 published anecdotal reports and case series have described patients with C. jejuni infection documented 1-3 weeks before onset of GBS. Cultures of fecal samples obtained at the onset of neurological symptoms from patients with GBS have yielded C. jejuni in more than 25% of cases. A relatively rare serotype, Penner type O19, is overrepresented among isolates of C. jejuni from Japanese patients with GBS. Serological studies suggest that 20%-40% of patients with GBS have evidence of recent C. jejuni infection. In summary, infection with C. jejuni is a common antecedent to GBS and probably plays a role in initiating demyelination; although several pathogenic mechanisms are possible, none has been proven.
Similar articles
-
Association between Campylobacter infection and Guillain-Barré syndrome.J Infect Dis. 1997 Dec;176 Suppl 2:S125-8. doi: 10.1086/513783. J Infect Dis. 1997. PMID: 9396695 Review.
-
Campylobacter jejuni infection as a cause of the Guillain-Barré syndrome.Infect Dis Clin North Am. 1998 Mar;12(1):173-84. doi: 10.1016/s0891-5520(05)70416-5. Infect Dis Clin North Am. 1998. PMID: 9494837 Review.
-
Does Campylobacter jejuni infection elicit "demyelinating" Guillain-Barre syndrome?Neurology. 2004 Aug 10;63(3):529-33. doi: 10.1212/01.wnl.0000133205.05169.04. Neurology. 2004. PMID: 15304587
-
Campylobacter jejuni strains from patients with Guillain-Barré syndrome.Emerg Infect Dis. 1998 Apr-Jun;4(2):263-8. doi: 10.3201/eid0402.980213. Emerg Infect Dis. 1998. PMID: 9621196 Free PMC article.
-
Improved serological diagnosis stresses the major role of Campylobacter jejuni in triggering Guillain-Barré syndrome.Clin Vaccine Immunol. 2006 Jul;13(7):779-83. doi: 10.1128/CVI.00065-06. Clin Vaccine Immunol. 2006. PMID: 16829615 Free PMC article.
Cited by
-
Role of Campylobacter jejuni infection in the pathogenesis of Guillain-Barré syndrome: an update.Biomed Res Int. 2013;2013:852195. doi: 10.1155/2013/852195. Epub 2013 Aug 13. Biomed Res Int. 2013. PMID: 24000328 Free PMC article. Review.
-
Colonization of a commercial broiler line by Campylobacter is under limited genetic control and does not significantly impair performance or intestinal health.Poult Sci. 2018 Dec 1;97(12):4167-4176. doi: 10.3382/ps/pey295. Poult Sci. 2018. PMID: 29982748 Free PMC article.
-
Post-Campylobacter Guillain Barré Syndrome in the USA: secondary analysis of surveillance data collected during the 2009-2010 novel Influenza A (H1N1) vaccination campaign.Epidemiol Infect. 2018 Oct;146(13):1740-1745. doi: 10.1017/S0950268818001802. Epub 2018 Jul 10. Epidemiol Infect. 2018. PMID: 29986777 Free PMC article.
-
Detection and identification of Campylobacter coli and Campylobacter jejuni by two-step polymerase chain reaction.Mol Biotechnol. 1995 Jun;3(3):266-8. doi: 10.1007/BF02789337. Mol Biotechnol. 1995. PMID: 7552696
-
Differentiation of Campylobacter jejuni serotype O19 strains from non-O19 strains by PCR.J Clin Microbiol. 1998 Dec;36(12):3567-73. doi: 10.1128/JCM.36.12.3567-3573.1998. J Clin Microbiol. 1998. PMID: 9817874 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
