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. 1993 Jun;134(2):455-64.
doi: 10.1093/genetics/134.2.455.

The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions

L Avery  1 , C I Bargmann, H R Horvitz
Affiliations

The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions

L Avery et al. Genetics. 1993 Jun.

Abstract

We have devised a method for selecting Caenorhabditis elegans mutants that execute feeding motions in the absence of food. One mutation isolated in this way is an allele of the gene unc-31, first discovered by S. Brenner in 1974, because of its effects on locomotion. We find that strong unc-31 mutations cause defects in four functions controlled by the nervous system. Mutant worms are lethargic, feed constitutively, are defective in egg-laying and produce dauer larvae that fail to recover. We discuss two extreme models to explain this pleiotropy: either unc-31 affects one or a few neurons that coordinately control several different functions, or it affects many neurons that independently control different functions.

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