Review
doi: 10.1016/0163-7258(93)90075-o.
Viral protein kinases and protein phosphatases
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- PMID: 8309996
- DOI: 10.1016/0163-7258(93)90075-o
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Review
Viral protein kinases and protein phosphatases
Pharmacol Ther.
1993 Sep.
Abstract
Certain large DNA viruses (e.g. herpesviruses and poxviruses) encode proteins related to cellular protein-serine/threonine kinases, and Hepatitis B virus and vesicular stomatitis virus may encode structurally different protein kinases. Other viruses activate cellular protein kinases, e.g. interferon-induced eukaryotic initiation factor-2 kinase, growth factor-induced kinases and protein kinases that regulate mitosis. Protein phosphatases are encoded by vaccinia virus and bacteriophage lambda and must also play a role in viral infection--as do cellular protein phosphatases. The functions of many of these viral enzymes remain to be determined, but they represent possible new targets for anti-viral therapy.
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