doi: 10.1126/science.8303301.
Prevention of vertebrate neuronal death by the crmA gene
Affiliations
- PMID: 8303301
- DOI: 10.1126/science.8303301
Item in Clipboard
Prevention of vertebrate neuronal death by the crmA gene
Science.
.
Erratum in
- Science 1994 Jun 3;264(5164):1388
Abstract
Interleukin-1 beta converting enzyme (ICE) is a mammalian homolog of CED-3, a protein required for programmed cell death in the nematode Caenorhabditis elegans. The activity of ICE can be specifically inhibited by the product of crmA, a cytokine response modifier gene encoded by cowpox virus. Microinjection of the crmA gene into chicken dorsal root ganglion neurons was found to prevent cell death induced by deprivation of nerve growth factor. Thus, ICE is likely to participate in neuronal death in vertebrates.
Comment in
-
Cell suicide: by ICE, not fire.Science. 1994 Feb 11;263(5148):754-6. doi: 10.1126/science.8303290. Science. 1994. PMID: 8303290 No abstract available.
Similar articles
-
Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3.Cell. 1993 Nov 19;75(4):653-60. doi: 10.1016/0092-8674(93)90486-a. Cell. 1993. PMID: 8242741
-
Involvement of an ICE-like protease in Fas-mediated apoptosis.Nature. 1995 May 4;375(6526):78-81. doi: 10.1038/375078a0. Nature. 1995. PMID: 7536900
-
Prevention of apoptosis in CNTF-dependent neurons by a mutant ICE and by viral protein CrmA but not by proto-oncogene product Bcl-2.Cell Death Differ. 1996 Jan;3(1):105-12. Cell Death Differ. 1996. PMID: 17180061
-
Apoptosis. Breaking the ICE.Curr Biol. 1994 Apr 1;4(4):337-40. doi: 10.1016/s0960-9822(00)00073-7. Curr Biol. 1994. PMID: 7857398 Review.
-
Ced-3/ICE: evolutionarily conserved regulation of cell death.Bioessays. 1994 Jun;16(6):387-9. doi: 10.1002/bies.950160604. Bioessays. 1994. PMID: 8080427 Review. No abstract available.
Cited by
-
Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition.Protein Sci. 2000 Aug;9(8):1423-7. doi: 10.1110/ps.9.8.1423. Protein Sci. 2000. PMID: 10975564 Free PMC article.
-
Antiviral actions of interferons.Clin Microbiol Rev. 2001 Oct;14(4):778-809, table of contents. doi: 10.1128/CMR.14.4.778-809.2001. Clin Microbiol Rev. 2001. PMID: 11585785 Free PMC article. Review.
-
Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product.J Virol. 1996 Sep;70(9):6479-85. doi: 10.1128/JVI.70.9.6479-6485.1996. J Virol. 1996. PMID: 8709286 Free PMC article.
-
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9042-6. doi: 10.1073/pnas.92.20.9042. Proc Natl Acad Sci U S A. 1995. PMID: 7568069 Free PMC article.
-
Prognostic value of bcl-2 expression in invasive breast cancer.Br J Cancer. 1995 Aug;72(2):354-60. doi: 10.1038/bjc.1995.338. Br J Cancer. 1995. PMID: 7640218 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
