A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice
- PMID: 8299692
- DOI: 10.1002/eji.1830240224
A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice
Abstract
We have found a new spontaneous autosomal recessive mutation in mice that causes a systemic absence of lymph nodes and Peyer's patches. The name "alymphoplasia", with the gene symbol "aly", is proposed for this mutant. The spleen of aly/aly mice is devoid of well-defined lymphoid follicles, and the thymus does not show a clear cortical-medullary distinction. The mutant homozygotes are deficient in both humoral and cell-mediated immune functions, and are highly susceptible to infections. They have a reduced level of IgM and severely depressed levels of IgG and IgA in their sera, and do not reject allogeneic skin grafts. However, they have mature T and B cells as determined from their cell surface antigens. The results of bone marrow transplantation experiments suggest a mesenchymal disorder as a possible cause of the lack of lymph nodes and of immunodeficiency in the aly mouse. The aly mutant mouse may be a useful animal model of primary immunodeficiency, as are the nu (nude) and scid (severe combined immunodeficiency) mice.
Similar articles
-
The splenic marginal zone is absent in alymphoplastic aly mutant mice.Eur J Immunol. 1996 Mar;26(3):669-75. doi: 10.1002/eji.1830260324. Eur J Immunol. 1996. PMID: 8605936
-
Development of intestinal intraepithelial T lymphocytes is independent of Peyer's patches and lymph nodes in aly mutant mice.J Immunol. 1994 Sep 1;153(5):2014-20. J Immunol. 1994. PMID: 8051406
-
Pathology of ALY mice: congenital immunodeficiency with lymph node and Peyer's patch defects.Immunobiology. 2000 Sep;202(3):213-25. doi: 10.1016/S0171-2985(00)80029-7. Immunobiology. 2000. PMID: 11045658
-
The nude mouse: a model of deficient T-cell function.Methods Achiev Exp Pathol. 1975;7:149-66. Methods Achiev Exp Pathol. 1975. PMID: 1105061 Review.
-
The athymic nude rat. Immunobiological characteristics with special reference to establishment of non-antigen-specific T-cell reactivity and induction of antigen-specific immunity.APMIS Suppl. 1991;21:1-39. APMIS Suppl. 1991. PMID: 2043379 Review.
Cited by
-
NF-κB inducing kinase: a key regulator in the immune system and in cancer.Cytokine Growth Factor Rev. 2010 Aug;21(4):213-26. doi: 10.1016/j.cytogfr.2010.06.002. Epub 2010 Aug 3. Cytokine Growth Factor Rev. 2010. PMID: 20685151 Free PMC article. Review.
-
Alymphoplasia (aly)-type nuclear factor kappaB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system.J Exp Med. 2000 May 1;191(9):1477-86. doi: 10.1084/jem.191.9.1477. J Exp Med. 2000. PMID: 10790423 Free PMC article.
-
The donor splice site mutation in NFkappaB-inducing kinase of alymphoplasia (aly/aly) mice.Immunogenetics. 2003 Jan;54(10):693-8. doi: 10.1007/s00251-002-0517-x. Epub 2002 Dec 3. Immunogenetics. 2003. PMID: 12557055
-
Interplay Between Non-Canonical NF-κB Signaling and Hepatitis B Virus Infection.Front Immunol. 2021 Sep 29;12:730684. doi: 10.3389/fimmu.2021.730684. eCollection 2021. Front Immunol. 2021. PMID: 34659217 Free PMC article. Review.
-
Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response.J Immunol. 2009 Aug 15;183(4):2205-12. doi: 10.4049/jimmunol.0804324. J Immunol. 2009. PMID: 19661265 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
