Comparative Study
doi: 10.1038/ng1293-359.
Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease
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- PMID: 8298643
- DOI: 10.1038/ng1293-359
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Comparative Study
Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease
Nat Genet.
1993 Dec.
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disorder. A gene defect located on the short arm of chromosome 16 is responsible for the disease in roughly 86% of affected European families. Using highly polymorphic microsatellite DNA markers, we have assigned a second gene for ADPKD to chromosome 4. In eight families with clear evidence against linkage to chromosome 16 markers, linkage analysis with the markers D4S231 and D4S423, demonstrated a multipoint lod score of 22.42.
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