Electron microscopic immunolocalization of GABA and glutamic acid decarboxylase (GAD) in cerebellar capillaries and their microenvironment
Affiliations
- PMID: 8298428
Item in Clipboard
Electron microscopic immunolocalization of GABA and glutamic acid decarboxylase (GAD) in cerebellar capillaries and their microenvironment
Cell Mol Biol (Noisy-le-grand).
1993 Dec.
Abstract
At present, it is known that a connection exists between neuronal activity and microvascular blood flow and permeability in the CNS. We have demonstrated the presence of immunoreactivities against both GABA and GAD as well in the endothelial capillary cells of rat cerebellar cortex, as in perivascular glia, neuronal bodies, dendrites and axon endings, in close association with the basal membrane of the pericyte or endothelial cells. These results support the suggestions from biochemical and pharmacological studies about the relationship between GABA and microvascular function in the CNS.
Similar articles
-
Neuromediators in the cerebellar blood-brain barrier and its microenvironment. Immunocytochemical demonstration of taurine, glycine, serotonin, thiamin and AATase.J Hirnforsch. 1994;35(1):31-8. J Hirnforsch. 1994. PMID: 8021455
-
Molecular and ultrastructural basis of the blood-brain barrier function. Immunohistochemical demonstration of Na+/K+ ATPase, alpha-actin, phosphocreatine and clathrin in the capillary wall and its microenvironment.Cell Mol Biol (Noisy-le-grand). 1993 Dec;39(8):819-28. Cell Mol Biol (Noisy-le-grand). 1993. PMID: 8298429
-
Synaptic and non-synaptic immunolocalization of GABA and glutamate acid decarboxylase (GAD) in cerebellar cortex of rat.Cell Mol Biol (Noisy-le-grand). 1993 Feb;39(1):115-23. Cell Mol Biol (Noisy-le-grand). 1993. PMID: 8467237
-
Axonal and non-axonal immunolocalization of cytosolic aspartate aminotransferase (cAATase), GABA and glutamic acid decarboxylase (GAD) in the rat cochlear nucleus.J Hirnforsch. 1992;33(6):637-44. J Hirnforsch. 1992. PMID: 1494041
-
Glutamic acid decarboxylase and GABA immunoreactivities in the cerebellar cortex of adult rat after prenatal exposure to a low concentration of carbon monoxide.Neuroscience. 2005;135(3):897-905. doi: 10.1016/j.neuroscience.2005.06.058. Epub 2005 Aug 19. Neuroscience. 2005. PMID: 16112480
Cited by
-
GABA immunoreactivity in the human cerebellar cortex: a light and electron microscopical study.Histochem J. 2001 Sep-Oct;33(9-10):537-43. doi: 10.1023/a:1014903908500. Histochem J. 2001. PMID: 12005025
-
Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease.Front Neuroenergetics. 2010 May 21;2:5. doi: 10.3389/fnene.2010.00005. eCollection 2010. Front Neuroenergetics. 2010. PMID: 20725515 Free PMC article.
-
Glutamic acid decarboxylase-positive neuronal cell bodies and terminals in the human cerebellar cortex.Histochem J. 2000 Sep;32(9):557-64. doi: 10.1023/a:1004106428844. Histochem J. 2000. PMID: 11127977
-
Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain.Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22290-5. doi: 10.1073/pnas.1011321108. Epub 2010 Dec 6. Proc Natl Acad Sci U S A. 2010. PMID: 21135230 Free PMC article.