Review
doi: 10.1016/0968-0004(93)90144-c.
DNA damage and the DNA-activated protein kinase
Affiliations
- PMID: 8291090
- DOI: 10.1016/0968-0004(93)90144-c
Item in Clipboard
Review
DNA damage and the DNA-activated protein kinase
Trends Biochem Sci.
1993 Nov.
Abstract
DNA-activated protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase that is activated in vitro by DNA fragments. The cellular targets of DNA-PK are nuclear, DNA-binding, regulatory proteins including Sp1, Fos, Jun, Myc, the tumor suppressor protein p53, and RNA polymerase II. These characteristics suggest a role for DNA-PK in coordinating nuclear processes and as a modulator of checkpoint mechanisms activated by DNA damage.
Similar articles
-
The nuclear serine/threonine protein kinase DNA-PK.Crit Rev Eukaryot Gene Expr. 1992;2(4):283-314. Crit Rev Eukaryot Gene Expr. 1992. PMID: 1486241 Review.
-
Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18.Eur J Biochem. 2004 Sep;271(18):3776-84. doi: 10.1111/j.1432-1033.2004.04319.x. Eur J Biochem. 2004. PMID: 15355354
-
A gel-electrophoretic analysis for improved sensitivity and specificity of DNA-dependent protein kinase activity.J Radiat Res. 1999 Jun;40(2):183-96. doi: 10.1269/jrr.40.183. J Radiat Res. 1999. PMID: 10494149
-
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.Nucleic Acids Res. 2004 Feb 10;32(3):997-1005. doi: 10.1093/nar/gkh265. Print 2004. Nucleic Acids Res. 2004. PMID: 14872059 Free PMC article.
-
Functions of the DNA dependent protein kinase.Cancer Surv. 1997;29:221-61. Cancer Surv. 1997. PMID: 9338103 Review.
Cited by
-
DNase I-resistant DNA-dependent protein kinase activity in Xenopus oocytes.Mol Cell Biochem. 2008 Feb;309(1-2):33-40. doi: 10.1007/s11010-007-9640-1. Epub 2007 Nov 1. Mol Cell Biochem. 2008. PMID: 17973081
-
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus.J Virol. 2006 Nov;80(22):11178-90. doi: 10.1128/JVI.01334-06. Epub 2006 Aug 23. J Virol. 2006. PMID: 16928741 Free PMC article.
-
Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination.Cell Cycle. 2011 Jun 15;10(12):1928-35. doi: 10.4161/cc.10.12.16011. Epub 2011 Jun 15. Cell Cycle. 2011. PMID: 21673501 Free PMC article. Review.
-
Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner.PLoS One. 2009;4(1):e4199. doi: 10.1371/journal.pone.0004199. Epub 2009 Jan 14. PLoS One. 2009. PMID: 19142223 Free PMC article.
-
Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development.Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13588-93. doi: 10.1073/pnas.94.25.13588. Proc Natl Acad Sci U S A. 1997. PMID: 9391070 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
