Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Jan 18;91(2):614-8.
doi: 10.1073/pnas.91.2.614.

Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver

T Toyonaga  1 , O Hino, S Sugai, S Wakasugi, K Abe, M Shichiri, K Yamamura
Affiliations

Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver

T Toyonaga et al. Proc Natl Acad Sci U S A. .

Abstract

Interferon-gamma may play an important role in the immune response and in inflammatory diseases, including chronic active hepatitis. To understand the role of interferon-gamma in the regulation of inflammation and to establish a mouse model of chronic active hepatitis, we produced transgenic mice in which the mouse interferon-gamma gene was regulated by a liver-specific promoter, the serum amyloid P component gene promoter. Four transgenic mouse lines were generated, and two of these lines expressed mRNA of interferon-gamma in the liver. Levels of serum transaminases increased gradually as a function of age and were significantly higher than those of interferon-gamma-negative littermates after 4 weeks after birth. One transgenic mouse line showed a histology of chronic active hepatitis similar to that found in human patients, although cirrhotic changes such as fibrosis were scarce. Thus, the liver-specific production of interferon-gamma is sufficient to induce chronic inflammatory disease and this mouse is a transgenic model of chronic active hepatitis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11523-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10036-40 - PubMed
    1. Prog Med Virol. 1978;24:40-69 - PubMed
    1. Lancet. 1981 Nov 21;2(8256):1129-33 - PubMed
    1. J Immunol. 1982 Dec;129(6):2773-8 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources