Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain
- PMID: 8247548
Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain
Abstract
Using a polymerase chain reaction-mediated approach we have characterized cDNAs from human and mouse origin representing a novel type of receptor protein tyrosine kinase (RTK). The deduced amino acid sequence (855 amino acids) of the longest open reading frame has a unique extracellular region encompassing a factor VIII-like domain, not previously described for RTKs. The most closely related RTKs are members of the neurotrophin receptors (TRK), which showed 47-49% homology with the kinase domain of the new RTK. Therefore, the new gene has been called TKT (Tyrosine-Kinase related to TRK). TKT orthologs from man and mouse were 98% similar. In both species a major transcript of 10 kb was found to be expressed at high levels in heart and lung. Low levels of this mRNA-species were detected in human brain, placenta, liver, skeletal muscle, kidney and in mouse brain and testis. Analysing human/mouse somatic cell hybrids we demonstrated that TKT segregates with human chromosome 1.
Similar articles
-
cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain.Genomics. 1995 Sep 20;29(2):426-37. doi: 10.1006/geno.1995.9985. Genomics. 1995. PMID: 8666391
-
Cloning and developmental expression of Nsk2, a novel receptor tyrosine kinase implicated in skeletal myogenesis.Oncogene. 1995 Jul 20;11(2):281-90. Oncogene. 1995. PMID: 7624144
-
Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and Gfm, and mapping of GFM to human chromosome 3q25.1-q26.2.Genomics. 2001 May 15;74(1):109-14. doi: 10.1006/geno.2001.6536. Genomics. 2001. PMID: 11374907
-
Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis.Genomics. 1998 Nov 1;53(3):315-24. doi: 10.1006/geno.1998.5433. Genomics. 1998. PMID: 9799598
-
Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases.Genomics. 2001 Oct;77(3):163-70. doi: 10.1006/geno.2001.6628. Genomics. 2001. PMID: 11597141
Cited by
-
Localization of the mouse gene encoding tyrosine kinase receptor type 10 on distal chromosome 1.Mamm Genome. 1997 Dec;8(12):941-2. doi: 10.1007/s003359900617. Mamm Genome. 1997. PMID: 9383291 No abstract available.
-
Upregulation of tyrosine kinase TKT by the Epstein-Barr virus transactivator Zta.J Virol. 2000 Aug;74(16):7391-9. doi: 10.1128/jvi.74.16.7391-7399.2000. J Virol. 2000. PMID: 10906192 Free PMC article.
-
Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells.Cell Commun Signal. 2023 Sep 19;21(1):244. doi: 10.1186/s12964-023-01252-8. Cell Commun Signal. 2023. PMID: 37726815 Free PMC article. Review.
-
Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma.Mol Cancer Ther. 2017 Nov;16(11):2473-2485. doi: 10.1158/1535-7163.MCT-16-0834. Epub 2017 Sep 1. Mol Cancer Ther. 2017. PMID: 28864681 Free PMC article.
-
DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.J Clin Invest. 2001 Nov;108(9):1369-78. doi: 10.1172/JCI12373. J Clin Invest. 2001. PMID: 11696582 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Other Literature Sources
Molecular Biology Databases
Miscellaneous