doi: 10.1038/366129a0.
The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction
Affiliations
- PMID: 8232552
- DOI: 10.1038/366129a0
Item in Clipboard
The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction
Nature.
.
Abstract
We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes.
Comment in
-
Signal transduction. Cytokine connections.Nature. 1993 Nov 11;366(6451):114-6. doi: 10.1038/366114a0. Nature. 1993. PMID: 8232550 No abstract available.
Similar articles
-
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.Nature. 1993 Nov 11;366(6451):166-70. doi: 10.1038/366166a0. Nature. 1993. PMID: 7901766
-
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.EMBO J. 1999 May 4;18(9):2480-8. doi: 10.1093/emboj/18.9.2480. EMBO J. 1999. PMID: 10228162 Free PMC article.
-
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.EMBO J. 1996 Feb 15;15(4):799-809. EMBO J. 1996. PMID: 8631301 Free PMC article.
-
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.Science. 1994 Jun 3;264(5164):1415-21. doi: 10.1126/science.8197455. Science. 1994. PMID: 8197455 Review.
-
[Dysfunction of host defence systems caused by virus infection].Tanpakushitsu Kakusan Koso. 1999 Jan;44(1):8-18. Tanpakushitsu Kakusan Koso. 1999. PMID: 10025169 Review. Japanese. No abstract available.
Cited by
-
Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy.Oncolytic Virother. 2015 Nov 20;4:183-91. doi: 10.2147/OV.S66081. eCollection 2015. Oncolytic Virother. 2015. PMID: 27512681 Free PMC article. Review.
-
IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages.Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):91-6. doi: 10.1073/pnas.97.1.91. Proc Natl Acad Sci U S A. 2000. PMID: 10618376 Free PMC article.
-
A time- and dose-dependent STAT1 expression system.BMC Biotechnol. 2006 Dec 21;6:48. doi: 10.1186/1472-6750-6-48. BMC Biotechnol. 2006. PMID: 17184522 Free PMC article.
-
Making a grade: Sonic Hedgehog signalling and the control of neural cell fate.EMBO J. 2009 Mar 4;28(5):457-65. doi: 10.1038/emboj.2009.12. Epub 2009 Feb 5. EMBO J. 2009. PMID: 19197245 Free PMC article. Review. No abstract available.
-
Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha.J Biol Chem. 2009 Sep 4;284(36):24328-40. doi: 10.1074/jbc.M109.021915. Epub 2009 Jun 26. J Biol Chem. 2009. PMID: 19561067 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
