doi: 10.1126/science.8211183.
A yeast protein similar to bacterial two-component regulators
Affiliations
- PMID: 8211183
- DOI: 10.1126/science.8211183
Item in Clipboard
A yeast protein similar to bacterial two-component regulators
Science.
.
Abstract
Many bacterial signaling pathways involve a two-component design. In these pathways, a sensor kinase, when activated by a signal, phosphorylates its own histidine, which then serves as a phosphoryl donor to an aspartate in a response regulator protein. The Sln1 protein of the yeast Saccharomyces cerevisiae has sequence similarities to both the histidine kinase and the response regulator proteins of bacteria. A missense mutation in SLN1 is lethal in the absence but not in the presence of the N-end rule pathway, a ubiquitin-dependent proteolytic system. The finding of SLN1 demonstrates that a mode of signal transduction similar to the bacterial two-component design operates in eukaryotes as well.
Comment in
-
The two-component pathway comes to eukaryotes.Science. 1993 Oct 22;262(5133):532. doi: 10.1126/science.8211179. Science. 1993. PMID: 8211179 No abstract available.
Similar articles
-
The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p.EMBO J. 1998 Dec 1;17(23):6952-62. doi: 10.1093/emboj/17.23.6952. EMBO J. 1998. PMID: 9843501 Free PMC article.
-
A two-component system that regulates an osmosensing MAP kinase cascade in yeast.Nature. 1994 May 19;369(6477):242-5. doi: 10.1038/369242a0. Nature. 1994. PMID: 8183345
-
Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus Candida albicans.Microbiology (Reading). 1998 Feb;144 ( Pt 2):425-432. doi: 10.1099/00221287-144-2-425. Microbiology (Reading). 1998. PMID: 9493379
-
Histidine phosphotransfer proteins in fungal two-component signal transduction pathways.Eukaryot Cell. 2013 Aug;12(8):1052-60. doi: 10.1128/EC.00083-13. Epub 2013 Jun 14. Eukaryot Cell. 2013. PMID: 23771905 Free PMC article. Review.
-
Bacterial histidine kinase as signal sensor and transducer.Int J Biochem Cell Biol. 2006 Mar;38(3):307-12. doi: 10.1016/j.biocel.2005.08.018. Epub 2005 Sep 26. Int J Biochem Cell Biol. 2006. PMID: 16242988 Review.
Cited by
-
Ssk1p-independent activation of Ssk2p plays an important role in the osmotic stress response in Saccharomyces cerevisiae: alternative activation of Ssk2p in osmotic stress.PLoS One. 2013;8(2):e54867. doi: 10.1371/journal.pone.0054867. Epub 2013 Feb 14. PLoS One. 2013. PMID: 23457455 Free PMC article.
-
Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway.Mol Cell Biol. 1998 Oct;18(10):5788-96. doi: 10.1128/MCB.18.10.5788. Mol Cell Biol. 1998. PMID: 9742096 Free PMC article.
-
Conserved sequence motifs in the unorthodox BvgS two-component sensor protein of Bordetella pertussis.Mol Gen Genet. 1996 Aug 27;252(1-2):169-76. doi: 10.1007/BF02173217. Mol Gen Genet. 1996. PMID: 8804390
-
Archaea: narrowing the gap between prokaryotes and eukaryotes.Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5761-4. doi: 10.1073/pnas.92.13.5761. Proc Natl Acad Sci U S A. 1995. PMID: 7597025 Free PMC article. Review. No abstract available.
-
Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway.Mol Cell Biol. 1999 Jan;19(1):182-93. doi: 10.1128/MCB.19.1.182. Mol Cell Biol. 1999. PMID: 9858543 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
