Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 Apr 15;13(8):1899-910.
doi: 10.1002/j.1460-2075.1994.tb06459.x.

Programmed cell death and Bcl-2 protection in the absence of a nucleus

M D Jacobson  1 , J F Burne, M C Raff
Affiliations
Comparative Study

Programmed cell death and Bcl-2 protection in the absence of a nucleus

M D Jacobson et al. EMBO J. .

Abstract

The molecular basis of programmed cell death (PCD) is unknown. An important clue is provided by the Bcl-2 protein, which can protect many cell types from PCD, although it is not known where or how it acts. Nuclear condensation, DNA fragmentation and a requirement for new RNA and protein synthesis are often considered hallmarks of PCD. We show here, however, that anucleate cytoplasts can undergo PCD and that Bcl-2 and extracellular survival signals can protect them, indicating that, in some cases at least, the nucleus is not required for PCD or for Bcl-2 or survival factor protection. We propose that PCD, like the cell cycle, is orchestrated by a cytoplasmic regulator that has multiple intracellular targets.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cell. 1993 Nov 19;75(4):641-52 - PubMed
    1. J Immunol. 1987 Nov 15;139(10):3199-206 - PubMed
    1. Trends Pharmacol Sci. 1989 Jul;10(7):281-5 - PubMed
    1. Cell. 1993 Aug 27;74(4):597-608 - PubMed
    1. Science. 1992 Dec 18;258(5090):1955-7 - PubMed

Publication types