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. 1994 Mar;120(3):473-81.
doi: 10.1242/dev.120.3.473.

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway

R J Diederich  1 , K Matsuno, H Hing, S Artavanis-Tsakonas
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Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway

R J Diederich et al. Development. 1994 Mar.

Abstract

Genetic data from Drosophila have suggested a functional relationship between the novel cytoplasmic protein encoded by the deltex locus and the transmembrane receptor encoded by Notch. We have demonstrated a direct interaction between these proteins from expression studies conducted in cultured cells, in yeast, and in the imaginal wing disc. deltex binds specifically to the Notch ankyrin repeats, a region that is crucial for Notch signaling and that constitutes the most conserved domain among Notch family members. In addition, we present a new Notch allele, Nsu42c, that is associated with a missense mutation within the fifth ankyrin repeat. In addition to representing a new class of viable Notch allele, this mutation behaves similarly to mutations of deltex and further implicates the ankyrin repeats in Notch function.

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