Rapid remodeling of retinal arbors in the tectum with and without blockade of synaptic transmission
- PMID: 8161460
- DOI: 10.1016/0896-6273(94)90343-3
Rapid remodeling of retinal arbors in the tectum with and without blockade of synaptic transmission
Abstract
Dynamic rearrangements of axon terminal arbors may be critical for establishing appropriate connections in the developing nervous system. Here, the changes in complex retinal axon arbors in the tecta of live Xenopus larvae were followed during the formation of the topographic retinotectal projection. Three-dimensional reconstructions of terminal arbors made with a confocal microscope at hourly intervals revealed rapid remodeling of arbor extensions. Shorter branches were extended and retracted very rapidly, suggesting that they probe the environment for the optimal sites to form stable branches. About 27% of longer branches were present throughout the entire observation period and may be sites of stabilized synaptic contacts. Treatment of the animals to block postsynaptic activity resulted in increased rates of arbor rearrangements, which may coincide with decreased synapse stability. These studies reveal the dynamic behavior of nerve arbors and provide estimates for the lifetimes of retinotectal branches.
Similar articles
-
In vivo observations of timecourse and distribution of morphological dynamics in Xenopus retinotectal axon arbors.J Neurobiol. 1996 Oct;31(2):219-34. doi: 10.1002/(SICI)1097-4695(199610)31:2<219::AID-NEU7>3.0.CO;2-E. J Neurobiol. 1996. PMID: 8885202
-
Cell-autonomous TrkB signaling in presynaptic retinal ganglion cells mediates axon arbor growth and synapse maturation during the establishment of retinotectal synaptic connectivity.J Neurosci. 2007 Mar 7;27(10):2444-56. doi: 10.1523/JNEUROSCI.4434-06.2007. J Neurosci. 2007. PMID: 17344382 Free PMC article.
-
Map formation in the developing Xenopus retinotectal system: an examination of ganglion cell terminal arborizations.J Neurosci. 1985 Dec;5(12):3228-45. doi: 10.1523/JNEUROSCI.05-12-03228.1985. J Neurosci. 1985. PMID: 3001241 Free PMC article.
-
Dynamics of axonal growth and the formation of orderly nerve connections in the fish retinotectal system.J Basic Clin Physiol Pharmacol. 1990 Jan-Dec;1(1-4):165-82. doi: 10.1515/jbcpp.1990.1.1-4.165. J Basic Clin Physiol Pharmacol. 1990. PMID: 2085511 Review. No abstract available.
-
Control of retinotectal axon arbor growth by postsynaptic CaMKII.Prog Brain Res. 1996;108:303-12. doi: 10.1016/s0079-6123(08)62548-0. Prog Brain Res. 1996. PMID: 8979810 Review. No abstract available.
Cited by
-
Development of callosal topography in visual cortex of normal and enucleated rats.J Comp Neurol. 2006 Jun 1;496(4):495-512. doi: 10.1002/cne.20938. J Comp Neurol. 2006. PMID: 16572463 Free PMC article.
-
Auditory experience refines cortico-basal ganglia inputs to motor cortex via remapping of single axons during vocal learning in zebra finches.J Neurophysiol. 2012 Feb;107(4):1142-56. doi: 10.1152/jn.00614.2011. Epub 2011 Dec 7. J Neurophysiol. 2012. PMID: 22157116 Free PMC article.
-
Computational modeling of retinotopic map development to define contributions of EphA-ephrinA gradients, axon-axon interactions, and patterned activity.J Neurobiol. 2004 Apr;59(1):95-113. doi: 10.1002/neu.10341. J Neurobiol. 2004. PMID: 15007830 Free PMC article.
-
Neuronal excitability as a regulator of circuit remodeling.Curr Biol. 2023 Mar 13;33(5):981-989.e3. doi: 10.1016/j.cub.2023.01.032. Epub 2023 Feb 8. Curr Biol. 2023. PMID: 36758544 Free PMC article.
-
Suppression of sprouting: An early function of NMDA receptors in the absence of AMPA/kainate receptor activity.J Neurosci. 1998 May 15;18(10):3725-37. doi: 10.1523/JNEUROSCI.18-10-03725.1998. J Neurosci. 1998. PMID: 9570803 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
