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. 1993 Sep 15;90(18):8529-33.
doi: 10.1073/pnas.90.18.8529.

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1

J E Sligh Jr  1 , C M Ballantyne, S S Rich, H K Hawkins, C W Smith, A Bradley, A L Beaudet
Affiliations

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1

J E Sligh Jr et al. Proc Natl Acad Sci U S A. .

Abstract

Gene targeting was used to produce mice deficient in intercellular adhesion molecule 1 (ICAM-1) or CD54, an immunoglobulin-like cell adhesion molecule that binds beta 2 integrins. Homozygous deficient animals develop normally, are fertile, and have a moderate granulocytosis. The nature of the mutation, RNA analysis, and immunostaining are consistent with complete loss of surface expression of ICAM-1. Deficient mice exhibit prominent abnormalities of inflammatory responses including impaired neutrophil emigration in response to chemical peritonitis and decreased contact hypersensitivity to 2,4-dinitrofluorobenzene. Mutant cells provided negligible stimulation in the mixed lymphocyte reaction, although they proliferated normally as responder cells. These mutant animals will be extremely valuable for examining the role of ICAM-1 and its counterreceptors in inflammatory disease processes and atherosclerosis.

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