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. 1993 May 1;90(9):4122-6.
doi: 10.1073/pnas.90.9.4122.

Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues

Z C Lai  1 , E Rushton, M Bate, G M Rubin
Affiliations

Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues

Z C Lai et al. Proc Natl Acad Sci U S A. .

Abstract

The Drosophila zfh-1 gene encodes an unusual protein with nine Cys2His2 type zinc-finger motifs and one homeodomain that shows a complex pattern of expression in the embryonic mesoderm and nervous system. To study the function of zfh-1, we generated loss-of-function zfh-1 mutations. Phenotypic analysis of zfh-1 mutant embryos reveals that the gene is not required for the initial segregation of the mesoderm or for the differentiation of mesodermally derived tissues. Rather, loss of zfh-1 function results in various degrees of local errors in cell fate or positioning.

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