doi: 10.1126/science.8091232.
Mediation of c-Myc-induced apoptosis by p53
Affiliations
- PMID: 8091232
- DOI: 10.1126/science.8091232
Item in Clipboard
Mediation of c-Myc-induced apoptosis by p53
Science.
.
Abstract
The cellular proto-oncogene c-myc is involved in cell proliferation and transformation but is also implicated in the induction of programmed cell death (apoptosis). The same characteristics have been described for the tumor suppressor gene p53, the most commonly mutated gene in human cancer. In quiescent mouse fibroblasts expressing wild-type p53 protein, activation of c-Myc was found to induce apoptosis and cell cycle reentry, preceded by stabilization of p53. In contrast, in quiescent p53-null fibroblasts, activation of c-Myc induced cell cycle reentry but not apoptosis. These results suggest that p53 mediates apoptosis as a safeguard mechanism to prevent cell proliferation induced by oncogene activation.
Similar articles
-
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.Genes Dev. 1994 Dec 1;8(23):2817-30. doi: 10.1101/gad.8.23.2817. Genes Dev. 1994. PMID: 7995520
-
Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts.Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10412-6. doi: 10.1073/pnas.91.22.10412. Proc Natl Acad Sci U S A. 1994. PMID: 7937965 Free PMC article.
-
c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5878-82. doi: 10.1073/pnas.91.13.5878. Proc Natl Acad Sci U S A. 1994. PMID: 8016082 Free PMC article.
-
c-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis.Cancer Biol Ther. 2011 Apr 1;11(7):615-26. doi: 10.4161/cbt.11.7.14688. Epub 2011 Apr 1. Cancer Biol Ther. 2011. PMID: 21278493 Free PMC article. Review.
-
MYC and the control of apoptosis.Cold Spring Harb Perspect Med. 2014 Jul 1;4(7):a014407. doi: 10.1101/cshperspect.a014407. Cold Spring Harb Perspect Med. 2014. PMID: 24985130 Free PMC article. Review.
Cited by
-
Unbalanced replication as a major source of genetic instability in cancer cells.Am J Blood Res. 2012;2(3):160-9. Epub 2012 Oct 20. Am J Blood Res. 2012. PMID: 23119227 Free PMC article.
-
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.Science. 2012 Jan 20;335(6066):348-53. doi: 10.1126/science.1212728. Epub 2011 Dec 8. Science. 2012. PMID: 22157079 Free PMC article.
-
Chemotherapy-Enabled Colorectal Cancer Immunotherapy of Self-Delivery Nano-PROTACs by Inhibiting Tumor Glycolysis and Avoiding Adaptive Immune Resistance.Adv Sci (Weinh). 2024 Apr;11(15):e2309204. doi: 10.1002/advs.202309204. Epub 2024 Jan 18. Adv Sci (Weinh). 2024. PMID: 38239040 Free PMC article.
-
c-Myc functionally cooperates with Bax to induce apoptosis.Mol Cell Biol. 2002 Sep;22(17):6158-69. doi: 10.1128/MCB.22.17.6158-6169.2002. Mol Cell Biol. 2002. PMID: 12167710 Free PMC article.
-
p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB.J Cell Biol. 1999 Nov 29;147(5):1063-72. doi: 10.1083/jcb.147.5.1063. J Cell Biol. 1999. PMID: 10579725 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
