doi: 10.1016/s0092-8674(94)90542-8.
Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex
Affiliations
- PMID: 8087848
- DOI: 10.1016/s0092-8674(94)90542-8
Item in Clipboard
Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex
Cell.
.
Abstract
We show here that the state of the p34cdc2-p56cdc13 mitotic B cyclin complex determines whether a fission yeast cell undergoes S phase or mitosis. Mutants defective for p56cdc13 reset to G1 and rereplicate their DNA, while cells completely lacking the p34cdc2-p56cdc13 complex undergo multiple rounds of S phase. In contrast, formation of the p34cdc2-p56cdc13 complex in G1 promotes cells inappropriately into mitosis. We propose that the temporal order of S phase and mitosis is maintained by the presence or absence of the p34cdc2-p56cdc13 complex.
Similar articles
-
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.Cell. 1995 Dec 15;83(6):1001-9. doi: 10.1016/0092-8674(95)90215-5. Cell. 1995. PMID: 8521500
-
p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle.EMBO J. 1997 Aug 1;16(15):4657-64. doi: 10.1093/emboj/16.15.4657. EMBO J. 1997. PMID: 9303310 Free PMC article.
-
A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.EMBO J. 1996 Feb 15;15(4):850-60. EMBO J. 1996. PMID: 8631306 Free PMC article.
-
A quantitative model for the cdc2 control of S phase and mitosis in fission yeast.Trends Genet. 1996 Sep;12(9):345-50. Trends Genet. 1996. PMID: 8855663 Review.
-
Regulation of G1 progression in fission yeast by the rum1+ gene product.Prog Cell Cycle Res. 1996;2:29-35. doi: 10.1007/978-1-4615-5873-6_3. Prog Cell Cycle Res. 1996. PMID: 9552380 Review.
Cited by
-
The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis.Plant Cell. 2004 Oct;16(10):2683-92. doi: 10.1105/tpc.104.024398. Epub 2004 Sep 17. Plant Cell. 2004. PMID: 15377755 Free PMC article.
-
A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.Genetics. 2005 Jan;169(1):77-89. doi: 10.1534/genetics.104.034231. Epub 2004 Sep 30. Genetics. 2005. PMID: 15466421 Free PMC article.
-
APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation.EMBO J. 2000 Aug 1;19(15):3945-55. doi: 10.1093/emboj/19.15.3945. EMBO J. 2000. PMID: 10921876 Free PMC article.
-
Plant geminivirus rep protein induces rereplication in fission yeast.J Virol. 2009 Jul;83(13):6769-78. doi: 10.1128/JVI.02491-08. Epub 2009 Apr 15. J Virol. 2009. PMID: 19369323 Free PMC article.
-
Preventing DNA over-replication: a Cdk perspective.Cell Div. 2008 Jan 22;3:3. doi: 10.1186/1747-1028-3-3. Cell Div. 2008. PMID: 18211690 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
