Skip to main page content
U.S. flag

An official website of the United States government

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 Apr;5(2):147-56.

Oncogenes and muscle differentiation: multiple mechanisms of interference

Affiliations
  • PMID: 8061330
Comparative Study

Oncogenes and muscle differentiation: multiple mechanisms of interference

S Alemà et al. Semin Cancer Biol. 1994 Apr.

Abstract

In vitro transformation of replicating myogenic cells by a variety of oncogenes is always accompanied by inhibition of the transition to the terminally differentiated state. Three main levels of interference by oncogenes may ultimately prevent transcription of skeletal muscle-specific genes. First, the transcription of muscle-regulatory factors (MRF) of the MyoD family can be extinguished in transformed myoblasts. Second, several oncoproteins are capable of silencing the transcriptional capacity of MRF. Third, the DNA binding activity of MRF can be negatively modulated by phosphorylation or competition by dominant negative partners. Oncogenes can function at multiple potential levels of regulation, depending on the myogenic cell context.

PubMed Disclaimer

Similar articles

Cited by

Publication types

Substances

LinkOut - more resources