lola encodes a putative transcription factor required for axon growth and guidance in Drosophila
- PMID: 8050351
- DOI: 10.1242/dev.120.6.1385
lola encodes a putative transcription factor required for axon growth and guidance in Drosophila
Abstract
Mutations in the gene longitudinals lacking (lola) lead to defects in the development of axon tracts in the Drosophila embryonic central nervous system. We now show that lola mutations also cause defects of axon growth and guidance in the peripheral nervous system, and causes a particular cluster of embryonic sense organs (lch5) to be oriented improperly. Axonal aberrations caused by lola are similar to those caused by mutations of three other genes, logo, Notch and Delta, raising the possibility that lola works in the same genetic pathway as do these other molecules. The lola gene encodes at least two nuclear protein products, apparently by differential RNA splicing. The predicted proteins contain an amino-terminal motif similar to that recently described for a family of transcription factors, including the products of the Drosophila genes tramtrack and the Broad Complex. Like Ttk and BR-C, one of the two characterized products of the lola locus bears sequences similar to the zinc-finger motif, but the other (neuronal) form of the protein has no recognizable DNA-binding motif.
Similar articles
-
A genome-wide analysis reveals that the Drosophila transcription factor Lola promotes axon growth in part by suppressing expression of the actin nucleation factor Spire.Neural Dev. 2011 Nov 30;6:37. doi: 10.1186/1749-8104-6-37. Neural Dev. 2011. PMID: 22129300 Free PMC article.
-
Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila.Nat Neurosci. 2003 Sep;6(9):917-24. doi: 10.1038/nn1105. Nat Neurosci. 2003. PMID: 12897787
-
Drosophila lola encodes a family of BTB-transcription regulators with highly variable C-terminal domains containing zinc finger motifs.Gene. 2003 Jun 5;311:59-69. doi: 10.1016/s0378-1119(03)00554-7. Gene. 2003. PMID: 12853139
-
Midline axon guidance in the Drosophila embryonic central nervous system.Semin Cell Dev Biol. 2019 Jan;85:13-25. doi: 10.1016/j.semcdb.2017.11.029. Epub 2017 Nov 27. Semin Cell Dev Biol. 2019. PMID: 29174915 Free PMC article. Review.
-
The NK-2 homeobox gene and the early development of the central nervous system of Drosophila.Ann N Y Acad Sci. 1995 Jun 30;758:224-42. doi: 10.1111/j.1749-6632.1995.tb24830.x. Ann N Y Acad Sci. 1995. PMID: 7625694 Review. No abstract available.
Cited by
-
Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination in Drosophila R7 photoreceptor cells.bioRxiv [Preprint]. 2024 Aug 7:2024.08.05.606616. doi: 10.1101/2024.08.05.606616. bioRxiv. 2024. PMID: 39149333 Free PMC article. Preprint.
-
Regulation of alternative splicing and polyadenylation in neurons.Life Sci Alliance. 2023 Oct 4;6(12):e202302000. doi: 10.26508/lsa.202302000. Print 2023 Dec. Life Sci Alliance. 2023. PMID: 37793776 Free PMC article. Review.
-
Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development.Nat Commun. 2023 Sep 21;14(1):5862. doi: 10.1038/s41467-023-41408-1. Nat Commun. 2023. PMID: 37735176 Free PMC article.
-
The Drosophila gene encoding JIG protein (CG14850) is critical for CrebA nuclear trafficking during development.Nucleic Acids Res. 2023 Jun 23;51(11):5647-5660. doi: 10.1093/nar/gkad343. Nucleic Acids Res. 2023. PMID: 37144466 Free PMC article.
-
A dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis.Cell Death Dis. 2022 Sep 2;13(9):756. doi: 10.1038/s41419-022-05195-9. Cell Death Dis. 2022. PMID: 36056003 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous