Review
doi: 10.1016/0968-0004(94)90005-1.
Raf meets Ras: completing the framework of a signal transduction pathway
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- PMID: 8048167
- DOI: 10.1016/0968-0004(94)90005-1
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Review
Raf meets Ras: completing the framework of a signal transduction pathway
Trends Biochem Sci.
1994 Jul.
Abstract
The Ras oncoprotein, a GTP-activated molecular switch, interacts directly with the Raf oncoprotein to recruit the MAP kinases and their subordinates. In this way, a mitogenic signal initiated by tyrosine kinases is converted by Ras into a wave of regulatory phosphorylation on serine and threonine residues that, depending on its intensity and duration, and the variety of substrates available, results in cell differentiation or cell division.
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