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. 1994 Jul 19;91(15):7306-10.
doi: 10.1073/pnas.91.15.7306.

C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line

J D Bretz  1 , S C Williams, M Baer, P F Johnson, R C Schwartz
Affiliations

C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line

J D Bretz et al. Proc Natl Acad Sci U S A. .

Abstract

C/EBP-related proteins 2 and 3 (CRP2 and CRP3) are differentially expressed by P388 lymphoblasts and their derivative P388D1(IL1) macrophages. We have ectopically expressed CRP2, the predominant CRP in macrophages, in P388 lymphoblasts. The expression of CRP2 is sufficient to confer the lipopolysaccharide (LPS)-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to lymphoblasts, which normally do not display LPS induction of inflammatory cytokines. Consistent with these findings, the expression of CRP2 antisense RNA blocks the LPS induction of IL-6 expression in P388D1(IL1) macrophages. This work clearly establishes the essential role of CRP2 in the induction of cytokine genes by LPS. Additionally, these data add MCP-1 to the list of cytokines showing an involvement of CRP2 in their expression.

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References

    1. J Immunol. 1989 Feb 15;142(4):1274-80 - PubMed
    1. J Immunol. 1981 Jun;126(6):2104-8 - PubMed
    1. Annu Rev Biochem. 1989;58:799-839 - PubMed
    1. Mol Cell Biol. 1989 Sep;9(9):4109-12 - PubMed
    1. Nucleic Acids Res. 1990 Jan 11;18(1):23-34 - PubMed

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