Review
doi: 10.1016/0955-0674(94)90132-5.
Structural and functional basis for hormone binding and receptor oligomerization
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- PMID: 8024806
- DOI: 10.1016/0955-0674(94)90132-5
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Review
Structural and functional basis for hormone binding and receptor oligomerization
Curr Opin Cell Biol.
1994 Apr.
Abstract
Most single-pass transmembrane receptors undergo a change in oligomeric state upon hormone binding. Recent mutational, biophysical and structural studies of the human growth hormone and tumor necrosis factor receptor complexes have revealed much about the mechanisms and molecular bases for binding and oligomerization. Principles learned from these examples and others should apply to many other hormone-receptor complexes.
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