Expression of cell adhesion molecules in inflammatory myopathies and Duchenne dystrophy
- PMID: 8021710
- DOI: 10.1097/00005072-199407000-00008
Expression of cell adhesion molecules in inflammatory myopathies and Duchenne dystrophy
Abstract
Cell adhesion molecules participate in target-effector cell interactions in cell-mediated cytotoxicity and in leukodiapedesis in inflammatory diseases. Two ligand-receptor pairs may play a role in the adhesion of cytotoxic T cells to their targets: 1) intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), and 2) LFA-3 and CD2. We therefore immunolocalized these molecules in myopathies where there is evidence for T cell-mediated myocytotoxicity, namely inclusion body myositis, polymyositis, and Duchenne dystrophy. Autoaggressive inflammatory cells close to invaded muscle fibers showed an increased expression of ICAM-1 and LFA-1. The nonnecrotic muscle fibers invaded by autoaggressive cells expressed ICAM-1 where their surfaces faced the invading cells. That immunoreactivity for ICAM-1 on the invading cells was distinct from that on the opposite muscle fiber surface was established by colocalization of ICAM-1 with the sarcolemmal marker dystrophin (or beta-spectrin) and was also confirmed by confocal microscopy. Leukodiapedesis in inflamed tissues is mediated by ICAM-1, LFA-3, vascular cell adhesion molecule-1 (VCAM-1), and E-selectin associated with endothelial cells. In dermatomyositis ICAM-1 was strongly expressed on endothelial cells of perimysial arterioles and venules and on some perifascicular capillaries. In all the other myopathies ICAM-1 and LFA-3 expressions were increased on endothelia of capillaries surrounded by inflammatory cells. VCAM-1 was detected in few arterioles in all diseases. E-selectin was not detected at any site in any disorder.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
-
Leucocyte/endothelial cell adhesion receptors in muscle biopsies from patients with idiopathic inflammatory myopathies (IIM).Clin Exp Immunol. 1996 Jun;104(3):467-73. Clin Exp Immunol. 1996. PMID: 9099932
-
[Expression of adhesion molecules in idiopathic inflammatory myopathies. Immunohistochemical study of 17 cases].Ann Pathol. 1999 Mar;19(1):12-8. Ann Pathol. 1999. PMID: 10320905 French.
-
Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells.Ann Neurol. 1984 Aug;16(2):193-208. doi: 10.1002/ana.410160206. Ann Neurol. 1984. PMID: 6383191
-
Cellular immune mechanisms in inflammatory myopathies.Curr Opin Rheumatol. 1997 Nov;9(6):520-6. doi: 10.1097/00002281-199711000-00007. Curr Opin Rheumatol. 1997. PMID: 9375281 Review.
-
Immunopathogenesis of inflammatory myopathies.Ann Neurol. 1995 May;37 Suppl 1:S74-86. doi: 10.1002/ana.410370709. Ann Neurol. 1995. PMID: 8968219 Review.
Cited by
-
Myogenic Cell Expression of Intercellular Adhesion Molecule-1 Contributes to Muscle Regeneration after Injury.Am J Pathol. 2020 Oct;190(10):2039-2055. doi: 10.1016/j.ajpath.2020.06.009. Epub 2020 Jul 8. Am J Pathol. 2020. PMID: 32650005 Free PMC article.
-
Signs of inflammation in both symptomatic and asymptomatic muscles from patients with polymyositis and dermatomyositis.Ann Rheum Dis. 2006 Dec;65(12):1565-71. doi: 10.1136/ard.2005.051086. Epub 2006 Jul 10. Ann Rheum Dis. 2006. PMID: 16831829 Free PMC article.
-
The molecular mechanism underlying dermatomyositis related interstitial lung disease: evidence from bioinformatic analysis and in vivo validation.Front Immunol. 2023 Oct 19;14:1288098. doi: 10.3389/fimmu.2023.1288098. eCollection 2023. Front Immunol. 2023. PMID: 37928522 Free PMC article.
-
Increased expression of cell adhesion molecules in myofasciitis.Front Neurol. 2023 May 9;14:1113404. doi: 10.3389/fneur.2023.1113404. eCollection 2023. Front Neurol. 2023. PMID: 37228411 Free PMC article.
-
Pathological pattern of Mdx mice diaphragm correlates with gradual expression of the short utrophin isoform Up71.Biochim Biophys Acta. 2006 Mar;1762(3):362-72. doi: 10.1016/j.bbadis.2005.11.006. Biochim Biophys Acta. 2006. PMID: 16457992 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous