Induction of developmentally programmed cell death and activation of HIV by sodium butyrate
- PMID: 8009866
- DOI: 10.1006/viro.1994.1372
Induction of developmentally programmed cell death and activation of HIV by sodium butyrate
Abstract
Apoptosis is an important regulatory process during normal development and maturation. We find that the proliferation-arresting and differentiation-inducing compound sodium n-butyrate (NaB) triggers a marked host chromatin degradation. This apoptotic process is independent of, but commensurate with, a rapid increase in viral mRNA synthesis and subsequent release of HIV-1 virus in transformed human cell lines harboring tat- (HLM1) or tat+ (U1, ACH-2) dormant HIV-1 proviruses. This compound stimulates a reversible accumulation of the characteristic viral mRNAs at a much faster rate than two other DNA degradation inducers such as tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate. The transcriptional activator butyrate analogue, alpha-amino-n-butyrate, failed to cause similar phenotypic changes. These results suggest that common regulatory signals may be involved in activation of apoptosis genes and latent provirus by NaB.
Similar articles
-
Rapid and sensitive detection of cell-associated HIV-1 in latently infected cell lines and in patient cells using sodium-n-butyrate induction and RT-PCR.J Med Virol. 1997 Jun;52(2):179-89. J Med Virol. 1997. PMID: 9179766
-
Induction of dormant HIV-1 by sodium butyrate: involvement of the TATA box in the activation of the HIV-1 promoter.AIDS. 1991 Jun;5(6):663-8. AIDS. 1991. PMID: 1883541
-
Sodium butyrate treatment of cells latently infected with HIV-1 results in the expression of unspliced viral RNA.Virology. 1993 Oct;196(2):496-505. doi: 10.1006/viro.1993.1505. Virology. 1993. PMID: 8372431
-
9-Nitrocamptothecin inhibits tumor recrosis factor-mediated activation of human immunodeficiency virus type 1 and enhances apoptosis in a latently infected T cell clone.AIDS Res Hum Retroviruses. 1998 Jan 1;14(1):39-49. doi: 10.1089/aid.1998.14.39. AIDS Res Hum Retroviruses. 1998. PMID: 9453250
-
Sodium butyrate stimulation of HIV-1 gene expression: a novel mechanism of induction independent of NF-kappa B.J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):332-9. J Acquir Immune Defic Syndr Hum Retrovirol. 1995. PMID: 7600100
Cited by
-
Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection.Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18786-91. doi: 10.1073/pnas.0905859106. Epub 2009 Oct 20. Proc Natl Acad Sci U S A. 2009. PMID: 19843699 Free PMC article.
-
Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription.Retrovirology. 2006 Nov 3;3:78. doi: 10.1186/1742-4690-3-78. Retrovirology. 2006. PMID: 17083724 Free PMC article.
-
Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.J Virol. 2004 Dec;78(24):13522-33. doi: 10.1128/JVI.78.24.13522-13533.2004. J Virol. 2004. PMID: 15564463 Free PMC article.
-
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.J Virol. 1997 Dec;71(12):9753-63. doi: 10.1128/JVI.71.12.9753-9763.1997. J Virol. 1997. PMID: 9371641 Free PMC article.
-
Low-Level Ionizing Radiation Induces Selective Killing of HIV-1-Infected Cells with Reversal of Cytokine Induction Using mTOR Inhibitors.Viruses. 2020 Aug 13;12(8):885. doi: 10.3390/v12080885. Viruses. 2020. PMID: 32823598 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
