Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 Dec 6;91(25):11973-7.
doi: 10.1073/pnas.91.25.11973.

The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast

T Lithgow  1 , T Junne, K Suda, S Gratzer, G Schatz
Affiliations
Comparative Study

The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast

T Lithgow et al. Proc Natl Acad Sci U S A. .

Abstract

We have cloned the gene encoding the protein Mas22p, which spans the outer membrane of yeast mitochondria. Cells that completely lack Mas22p are inviable. The plasmid-borne MAS22 gene suppresses several defects resulting from the deletion of one or more of the mitochondrial protein import receptors. Defects of Mas20p-deficient cells are explained by the reduced level of Mas22p in these mutants. Mas22p has one acidic domain in the cytosol and a second acidic domain in the mitochondrial intermembrane space. We suggest that these domains of Mas22p on either side of the outer membrane function as a relay system for transferring the basic targeting sequences of precursor proteins into the mitochondria.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 1989 Aug 10;340(6233):433-4 - PubMed
    1. J Biol Chem. 1994 May 27;269(21):15325-30 - PubMed
    1. J Biol Chem. 1990 Jan 25;265(3):1755-64 - PubMed
    1. Curr Genet. 1989 Dec;16(5-6):339-46 - PubMed
    1. EMBO J. 1990 Oct;9(10):3191-200 - PubMed

Publication types

MeSH terms

Associated data

LinkOut - more resources