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. 1994 Oct 28;204(2):950-8.
doi: 10.1006/bbrc.1994.2552.

Involvement of NF-kappa B activation in thrombin-induced human vascular smooth muscle cell proliferation

T Nakajima  1 , I Kitajima, H Shin, I Takasaki, K Shigeta, K Abeyama, Y Yamashita, T Tokioka, Y Soejima, I Maruyama
Affiliations

Involvement of NF-kappa B activation in thrombin-induced human vascular smooth muscle cell proliferation

T Nakajima et al. Biochem Biophys Res Commun. .

Abstract

A thrombin receptor has been cloned and is thought to mediate a variety of thrombin-induced responses. However, the transcription factors important for postreceptor signaling have been little clarified. The post-receptor signals are mediated by several protein kinases responsible for NF-kappa B activation, and most thrombin-inducible genes have the kappa B sequence in the regulatory elements. The possibility that NF-kappa B may participate in thrombin signaling was therefore investigated in cultured human vascular smooth muscle cells (VSMCs). Thrombin receptor stimulation resulted in activation of NF-kappa B. Furthermore, treatment of cells with antisense p65 ODNs of NF-kappa B inhibited thrombin-stimulated growth of VSMC in vitro. Results indicate that the activation of NF-kappa B is involved in thrombin signaling and that this pathway causes the proliferation of VSMC induced by thrombin. Therapeutic potential of antisense NF-kappa B ODNs for the treatment with atherosclerosis and restenosis is also indicated.

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