Abnormalities of the blood-brain barrier in global cerebral ischemia in rats due to experimental cardiac arrest
- PMID: 7976565
- DOI: 10.1007/978-3-7091-9334-1_73
Abnormalities of the blood-brain barrier in global cerebral ischemia in rats due to experimental cardiac arrest
Abstract
The aim of the study was to characterize the impact of global cerebral ischemia resulting from cardiac arrest on the BBB permeability. Survival time of experimental animals after 3.5, 5 or 10 min ischemia range from 3.5-10 min to 24 h. Vascular permeability was evaluated with horseradish peroxidase (HRP). BBB disturbances were of biphasic nature. In the first phase, appearing immediately after ischemia and persisting till 1st postischemic hour, HRP extravasation involved mainly venous site of microcirculation and was limited to the cerebral and cerebellar cortex and the central periventricular structures. The second phase covering the period between 6 and 24 h after resuscitation was characterized by random HRP leakage in all the CNS structures. HRP penetrated through increased microvesicular and canalicular endothelial systems, through interendothelial junctions and via disintegrated endothelial cells. Distribution and perivenous localization of BBB changes in early phase suggests their connection with venostasis resulting from cardiac arrest. The second phase seems to be pathogenetically related with the consequences of the ischemic process.
Similar articles
-
Early blood-brain barrier changes in the rat following transient complete cerebral ischemia induced by cardiac arrest.Brain Res. 1994 Jan 7;633(1-2):41-52. doi: 10.1016/0006-8993(94)91520-2. Brain Res. 1994. PMID: 8137172
-
Blood-brain barrier permeability to micromolecules and edema formation in the early phase of incomplete continuous ischemia.Acta Neuropathol. 1991;82(2):107-11. doi: 10.1007/BF00293952. Acta Neuropathol. 1991. PMID: 1927266
-
The importance of brain temperature in alterations of the blood-brain barrier following cerebral ischemia.J Neuropathol Exp Neurol. 1990 Sep;49(5):486-97. doi: 10.1097/00005072-199009000-00004. J Neuropathol Exp Neurol. 1990. PMID: 2273405
-
Structural pathways for macromolecular and cellular transport across the blood-brain barrier during inflammatory conditions. Review.Histol Histopathol. 2004 Apr;19(2):535-64. doi: 10.14670/HH-19.535. Histol Histopathol. 2004. PMID: 15024715 Review.
-
Past and recent BBB studies with particular emphasis on changes in ischemic brain edema: dedicated to the memory of Dr. Igor Klatzo.Acta Neurochir Suppl. 2010;106:21-7. doi: 10.1007/978-3-211-98811-4_3. Acta Neurochir Suppl. 2010. PMID: 19812915 Review.
Cited by
-
Cell-Permeable Peptide Targeting the Nrf2-Keap1 Interaction: A Potential Novel Therapy for Global Cerebral Ischemia.J Neurosci. 2015 Nov 4;35(44):14727-39. doi: 10.1523/JNEUROSCI.1304-15.2015. J Neurosci. 2015. PMID: 26538645 Free PMC article.
-
A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity.Fluids Barriers CNS. 2020 Nov 18;17(1):69. doi: 10.1186/s12987-020-00230-3. Fluids Barriers CNS. 2020. PMID: 33208141 Free PMC article. Review.
-
Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer's Disease Phenotype.Int J Mol Sci. 2018 Dec 12;19(12):4002. doi: 10.3390/ijms19124002. Int J Mol Sci. 2018. PMID: 30545070 Free PMC article. Review.
-
Brain ischemia and ischemic blood-brain barrier as etiological factors in sporadic Alzheimer's disease.Neuropsychiatr Dis Treat. 2008 Oct;4(5):855-64. doi: 10.2147/ndt.s3739. Neuropsychiatr Dis Treat. 2008. PMID: 19183778 Free PMC article.
-
Peripheral markers of brain damage and blood-brain barrier dysfunction.Restor Neurol Neurosci. 2003;21(3-4):109-21. Restor Neurol Neurosci. 2003. PMID: 14530574 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Medical