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. 1994 Oct 17;13(20):4798-806.
doi: 10.1002/j.1460-2075.1994.tb06805.x.

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes

L F Reis  1 , H Ruffner, G Stark, M Aguet, C Weissmann
Affiliations

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes

L F Reis et al. EMBO J. .

Abstract

The transcription factor interferon regulatory factor 1 (IRF-1) binds tightly to the interferon (IFN)-beta promoter and has been implicated in the induction of type I IFNs. We generated mice devoid of functional IRF-1 by targeted gene disruption. As reported by others, IRF-1-deficient mice showed a discrete phenotype: the CD4/CD8 ratio was increased and IFN-gamma-induced levels of macrophage iNO synthase mRNA were strongly diminished. However, type I IFN induction in vivo by virus or double-stranded RNA was unimpaired, as evidenced by serum IFN titers and IFN mRNA levels in spleen, liver and lung. There was also no impairment in the response of type I IFN-inducible genes. Therefore, IRF-1 is not essential for these processes in vivo.

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References

    1. Proc Natl Acad Sci U S A. 1970 Sep;67(1):464-71 - PubMed
    1. Science. 1994 Jun 24;264(5167):1918-21 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3909-13 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3409-13 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Dec;78(12):7426-30 - PubMed

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