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. 1994 Jun;40(2):111-22.
doi: 10.1016/0198-8859(94)90055-8.

Influence of HLA class I and class II antigens on the peripheral T-cell receptor repertoire

E F Reed  1 , S L Tugulea, N Suciu-Foca
Affiliations

Influence of HLA class I and class II antigens on the peripheral T-cell receptor repertoire

E F Reed et al. Hum Immunol. 1994 Jun.

Abstract

Using TCR-specific mAbs, we analyzed the TCR distribution in the CD4 and CD8 compartments of peripheral blood T cells from members of six families, including two which were informative for an HLA-B/DR crossover. TCR distribution in the CD4 compartment is influenced by MHC class II antigens as it was similar in the child carrying the HLA-B/DR recombination and in the HLA-DR-identical sibling. There was also a relatively small degree of difference between TCR distribution in the CD8 compartment of a child with an HLA-B/DR crossover and his HLA class-I-identical sibling. Analysis of TCR V beta gene usage in the CD4 compartment of unrelated individuals sharing an HLA-DR allele showed an increased usage of V beta 8a and V beta 12a in DR4-positive subjects. These data suggest that studies of TCR V beta gene usage in individuals with HLA-associated autoimmune diseases may provide further information about MHC-dependent biases in the T-cell repertoire.

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