Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Oct;98(1):83-8.
doi: 10.1111/j.1365-2249.1994.tb06611.x.

Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease

R Giacomelli  1 , I Parzanese, G Frieri, A Passacantando, F Pizzuto, T Pimpo, P Cipriani, A Viscido, R Caprilli, G Tonietti
Affiliations

Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease

R Giacomelli et al. Clin Exp Immunol. 1994 Oct.

Abstract

In order to study the role of gamma/delta T cells in the pathogenesis of inflammatory bowel disease (IBD) in humans, we measured the percentage of these cells in the peripheral blood, assessed the ratio of the non-disulphide-linked (delta TCS1) type of T cell receptor (TCR) in the total gamma/delta T cells, studied the co-expression of gamma/delta TCR and accessory molecules CD8 and CD16, and compared these data with both the type and the activity of the disease. Percentage levels and absolute numbers of gamma/delta+ T cells were higher in active patients than in controls (P < 0.05), mainly as a result of an increase of V delta 1+ (delta TCS1) T cell subset (P < 0.05). This trend was strongly retained independently of disease activity and clinical picture. An increased percentage of TCR delta 1+/CD16+ cells was observed in our patients compared with controls (P < 0.05). In contrast, no difference was observed as far as the TCR delta 1+/CD8+ cells were concerned. These results suggest that IBD is associated with an expansion of gamma/delta T cells in peripheral blood, which may play a role in the pathogenesis of these disorders.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gastroenterology. 1984 Jan;86(1):13-22 - PubMed
    1. J Rheumatol. 1991 Oct;18(10):1504-10 - PubMed
    1. Adv Immunol. 1986;38:1-30 - PubMed
    1. Nature. 1986 Jul 10-16;322(6075):145-9 - PubMed
    1. Nature. 1987 Feb 19-25;325(6106):689-94 - PubMed

Publication types

MeSH terms

Substances