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. 1995 Mar 25;345(8952):759-61.
doi: 10.1016/s0140-6736(95)90641-x.

Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma

Y Q Huang  1 , J J Li, M H Kaplan, B Poiesz, E Katabira, W C Zhang, D Feiner, A E Friedman-Kien
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Free article

Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma

Y Q Huang et al. Lancet. .
Free article

Abstract

The association between a new human herpesvirus-like agent and various forms of Kaposi's sarcoma was examined by PCR. The DNA sequences of this agent were detected in 7 of 8 classic Kaposi's sarcoma specimens, 12 of 12 AIDS-associated specimens from the United States, and 7 of 10 specimens from African endemic Kaposi's sarcoma. Polymorphism of the herpesvirus-like DNA in the Kaposi's tissue from different populations was observed by both single-strand conformational polymorphism and direct sequencing. Furthermore, the presence and expression of the virus was detected in some Kaposi's tumours by Southern and northern blotting. This herpesvirus may be involved in the pathogenesis of different kinds of Kaposi's sarcoma seen among distinct and unrelated populations.

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  • Kaposi's sarcoma and new herpesvirus.
    Lebbé C, de Crémoux P, Rybojad M, Costa da Cunha C, Morel P, Calvo F. Lebbé C, et al. Lancet. 1995 May 6;345(8958):1180. doi: 10.1016/s0140-6736(95)91011-5. Lancet. 1995. PMID: 7723569 No abstract available.

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